胶质母细胞瘤中的CD133阴性癌症干细胞
CD133 negative cancer stem cells in glioblastoma.
作者信息
Beier Christoph P, Beier Dagmar
机构信息
Department of Neurology, RWTH Aachen, Medical School, Aachen, Germany.
出版信息
Front Biosci (Elite Ed). 2011 Jan 1;3(2):701-10. doi: 10.2741/e280.
Glioblastomas (GBM) are paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Recently, the discovery of CD133- CSC in addition to CD133+ CSC has substantially added to our understanding of the complexity of GBM CSC. This review gives an overview on our current knowledge on CD133- cells in GBM and describes five different hypothesizes on the nature of CD133- cells in GBM. In addition, we summarize the current knowledge on tumorigenic CD133- CSC, list available markers, describe the current controversies on the origin of CD133- CSC, and discuss how the heterogeneity of CSC may correspond to the molecular heterogeneity of GBM.
胶质母细胞瘤（GBM）是实体瘤中癌症干细胞（CSC）研究的典范。最近，除了CD133 + CSC之外，CD133 - CSC的发现极大地增进了我们对GBM CSC复杂性的理解。本综述概述了我们目前对GBM中CD133 - 细胞的认识，并描述了关于GBM中CD133 - 细胞性质的五种不同假设。此外，我们总结了目前关于致瘤性CD133 - CSC的知识，列出了可用的标志物，描述了关于CD133 - CSC起源的当前争议，并讨论了CSC的异质性如何与GBM的分子异质性相对应。
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