Kullberg Joel, Sundbom Magnus, Haenni Arvo, Freden Susanne, Johansson Lars, Börnert Peter, Ahlström Anders, Ahlström Håkan, Karlsson Anders
Department of Radiology, Uppsala University, 751 85 Uppsala, Sweden.
J Obes. 2011;2011:959601. doi: 10.1155/2011/959601. Epub 2010 Dec 21.
Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: -8.0 kg, n = 13). Relative body fat changes were smaller after LCD than after GBP (-7.1 ± 3.6% versus -10 ± 3.2%, P = .029, n = 13). Liver fat fell during the LCD month (-41%, P = .001, n = 13) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed.
背景。最近，我们发现胃旁路手术（GBP）一个月后内脏脂肪和皮下脂肪大幅减少，而肝脏脂肪含量没有任何变化。目的。首先，描述术前低热量饮食（LCD）一个月及随后GBP术后一个月体重减轻引起的脂质动员情况；其次，参考我们之前单独进行GBP干预后的发表结果来讨论这些观察结果。方法。对15名病态肥胖女性在LCD前、GBP时及GBP术后一个月进行研究。通过磁共振技术和血液检测来测量对代谢的影响。结果。两个月后体重均有类似程度的减轻（平均：-8.0千克，n = 13）。LCD后相对体脂变化小于GBP后（-7.1±3.6%对-10±3.2%，P = 0.029，n = 13）。在LCD期间肝脏脂肪下降（-41%，P = 0.001，n = 13），但GBP术后一个月未改变（+12%）。结论。胃旁路手术似乎比类似的LCD引起的体重减轻导致更大的脂质动员。人们可以推测，GBP改变的胃肠信号使脂肪组织对脂肪分解敏感，从而促进了所观察到的变化。
