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Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.阻断 TrkB 介导的磷酯酶 Cγ 信号传递可抑制边缘性癫痫的发生。
J Neurosci. 2010 May 5;30(18):6188-96. doi: 10.1523/JNEUROSCI.5821-09.2010.
2
Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.脑源性神经营养因子（BDNF）信使核糖核酸（mRNA）的树突运输由反式转运蛋白介导，并被G196A（Val66Met）突变阻断。
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16481-6. doi: 10.1073/pnas.0902833106. Epub 2009 Sep 9.
3
C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.C3PO，一种通过促进RNA诱导沉默复合体（RISC）激活来促进RNA干扰（RNAi）的核糖核酸酶。
Science. 2009 Aug 7;325(5941):750-3. doi: 10.1126/science.1176325.
4
Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons.长3'UTR脑源性神经营养因子mRNA在海马神经元脊柱形态和突触可塑性中的独特作用。
Cell. 2008 Jul 11;134(1):175-87. doi: 10.1016/j.cell.2008.05.045.
5
Activity-dependent expression of brain-derived neurotrophic factor in dendrites: facts and open questions.脑源性神经营养因子在树突中的活性依赖性表达：事实与未解决的问题。
Neurosci Res. 2008 Aug;61(4):335-46. doi: 10.1016/j.neures.2008.04.013. Epub 2008 May 4.
6
The Translin/Trax RNA binding complex: clues to function in the nervous system.反式转运蛋白/Trax RNA结合复合体：神经系统功能线索
Biochim Biophys Acta. 2008 Aug;1779(8):479-85. doi: 10.1016/j.bbagrm.2008.03.008. Epub 2008 Apr 3.
7
Contribution of Translin to hematopoietic regeneration after sublethal ionizing irradiation.
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8
BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?脑源性神经营养因子：蛋白质合成依赖性长时程增强和长期记忆的关键调节因子？
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9
BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae.脑源性神经营养因子（BDNF）信使核糖核酸（mRNA）剪接变体表现出活性依赖的靶向不同海马层的特性。
Mol Cell Neurosci. 2008 Jan;37(1):11-9. doi: 10.1016/j.mcn.2007.08.011. Epub 2007 Aug 23.
10
Dendritic protein synthesis, synaptic plasticity, and memory.树突状蛋白合成、突触可塑性与记忆。
Cell. 2006 Oct 6;127(1):49-58. doi: 10.1016/j.cell.2006.09.014.

脑源性神经营养因子 mRNA 的树突运输：依赖和不依赖转铁蛋白的调节机制。

Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.

机构信息

Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

出版信息

J Neurochem. 2011 Mar;116(6):1112-21. doi: 10.1111/j.1471-4159.2010.07166.x. Epub 2011 Jan 20.

DOI:10.1111/j.1471-4159.2010.07166.x
PMID:21198640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3050072/
Abstract

Dendritic trafficking and translation of brain-derived neurotrophic factor (BDNF) transcripts play a key role in mediating synaptic plasticity. Recently, we demonstrated that siRNA-mediated knockdown of translin, an RNA-binding protein, impairs KCl-induced dendritic trafficking of BDNF mRNA in cultured hippocampal neurons. We have now assessed whether translin deletion impairs dendritic trafficking of BDNF mRNA in hippocampal neurons in vivo. We have found that translin and its partner protein, trax, undergo dendritic translocation in response to treatment with pilocarpine, a pro-convulsant muscarinic agonist that increases dendritic trafficking of BDNF mRNA in hippocampal neurons. In translin knockout mice, the basal level of dendritic BDNF mRNA is decreased in CA1 pyramidal neurons. However, translin deletion does not block pilocarpine's ability to increase dendritic trafficking of BDNF mRNA indicating that the requirement for translin in this process varies with the stimulus employed to drive it. Consistent with this inference, we found that dendritic trafficking of BDNF mRNA induced by bath application of recombinant BDNF in cultured hippocampal neurons, is not blocked by siRNA-mediated knockdown of translin. Taken together, these in vivo and in vitro findings indicate that dendritic trafficking of BDNF mRNA can be mediated by both translin-dependent and -independent mechanisms.

摘要

树突运输和脑源性神经营养因子 (BDNF) 转录本的翻译在调节突触可塑性中起着关键作用。最近，我们证明，siRNA 介导的 RNA 结合蛋白转铁蛋白的敲低会损害培养的海马神经元中 KCl 诱导的 BDNF mRNA 的树突运输。我们现在评估转铁蛋白缺失是否会损害体内海马神经元中 BDNF mRNA 的树突运输。我们发现，转铁蛋白及其伴侣蛋白 trax 在毛果芸香碱（一种增加海马神经元中 BDNF mRNA 树突运输的促惊厥毒蕈碱激动剂）处理下发生树突易位。在转铁蛋白敲除小鼠中，CA1 锥体神经元中树突状 BDNF mRNA 的基础水平降低。然而，转铁蛋白缺失并不阻止毛果芸香碱增加 BDNF mRNA 的树突运输，表明在该过程中转铁蛋白的需求因所采用的刺激而有所不同。与这一推断一致，我们发现，在培养的海马神经元中，用重组 BDNF 进行浴处理诱导的 BDNF mRNA 的树突运输，不会被转铁蛋白 siRNA 介导的敲低所阻断。总之，这些体内和体外的发现表明，BDNF mRNA 的树突运输可以通过转铁蛋白依赖和非依赖的机制来介导。