Department of Neurology, University of Ulm, Ulm, Germany.
Eur J Neurol. 2011 Jun;18(6):882-7. doi: 10.1111/j.1468-1331.2010.03310.x. Epub 2010 Dec 29.
Hippocampal sulcal cavities (HSC) have been speculated to contribute to a higher vulnerability of memory pathways and might be a possible etiological factor in transient global amnesia (TGA). Therefore, we evaluated the influence of HSC on cognitive long-term outcome in TGA-patients.
Fourteen otherwise healthy patients with the clinical syndrome of TGA in their history underwent a high-resolution magnetic resolution imaging and a comprehensive neuropsychological test battery. The neuropsychological control group consisted of 15 healthy subjects and was balanced for age, sex and other risk factors as well as intellectual and social status.
Magnetic resolution imaging and neuropsychological testing have been performed 1128 days (median) after the TGA. HSC have been detected in nine of the 14 patients and have been bilateral in eight of them. There were no differences in cognitive performance in patients with and without HSC as well as compared to healthy subjects. Even in patients with greater lesion load, only a slight visuospatial deficit was found.
Although an increased incidence of HSCs is detected in TGA patients, cavities are not obligatorily in TGA. Moreover, even patients with hippocampal cavities achieve a full neuropsychological recovery independent of the frequency and size of the hippocampal lesions.
海马沟裂（HSC）被推测会增加记忆通路的脆弱性，并且可能是短暂性全面遗忘症（TGA）的一个潜在病因。因此，我们评估了 HSC 对 TGA 患者认知长期预后的影响。
14 名既往有 TGA 临床综合征的健康患者接受了高分辨率磁共振成像和全面神经心理学测试。神经心理学对照组由 15 名健康受试者组成，在年龄、性别和其他风险因素以及智力和社会地位方面进行了平衡。
TGA 后中位 1128 天进行了磁共振成像和神经心理学测试。在 14 名患者中有 9 名检测到 HSC，其中 8 名患者为双侧。有 HSC 和无 HSC 的患者以及与健康受试者的认知表现均无差异。即使在病变负荷较大的患者中，也仅发现轻微的视觉空间缺陷。
尽管在 TGA 患者中检测到 HSC 的发生率增加，但在 TGA 中并非必须存在。此外，即使是有海马腔的患者，也能独立于海马病变的频率和大小实现完全的神经心理学恢复。
