Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Neurogastroenterol Motil. 2011 Apr;23(4):387-90, e171. doi: 10.1111/j.1365-2982.2010.01651.x.
Colonic propagating sequences (PS) are important for the movement of colonic content and defecation, and aberrant PS patterning has been associated with slow transit constipation. However, because these motor patterns are typically recorded over long periods (24 h +), the visualization of PS spatiotemporal patterning is difficult. Here, we develop a novel method for displaying pan-colonic motility patterns.
A 3D mesh representing the geometry of the human colon was created as follows: (i) Human colon images from the Visible Human Dataset were digitized to create a 3D data cloud, and (ii) A surface mesh was fitted to the cloud using a least-squares minimization technique. Colonic manometry catheters were placed in the ascending colon of healthy controls and patients with slow transit constipation (STC), with the aid of a colonoscope. The colonic manometry data were interpolated and mapped to the model according to the following anatomical landmarks: cecum, hepatic flexure, splenic flexure, sigmoid-descending junction, and anus.
These 3D images clearly and intuitively communicate characteristics of normal and abnormal colonic motility. Specifically we have shown the reduced amplitude of the antegrade propagating pressure waves (PPW) throughout the colon and reduced frequency of PPWs at the mid-colon in patients with STC.
A novel method for the 3D visualization of PS is presented, providing an intuitive method for representing a large volume of physiological data. These techniques can be used to display frequency, amplitude or velocity data, and will help to convey regions of abnormally in patient populations.
结肠推进性序列（PS）对结肠内容物的运动和排便很重要，异常的 PS 模式与传输缓慢性便秘有关。然而，由于这些运动模式通常记录时间较长（24 小时+），因此 PS 时空模式的可视化较为困难。在这里，我们开发了一种显示全结肠运动模式的新方法。
按照以下步骤创建表示人类结肠几何形状的 3D 网格：（i）对 Visible Human Dataset 中的人类结肠图像进行数字化，以创建 3D 数据云；（ii）使用最小二乘法拟合技术对云进行表面网格拟合。借助结肠镜，将结肠测压导管放置在健康对照者和传输缓慢性便秘（STC）患者的升结肠中。根据以下解剖学标志将结肠测压数据插值并映射到模型上：盲肠、肝曲、脾曲、乙状结肠-降结肠交界处和肛门。
这些 3D 图像清晰直观地传达了正常和异常结肠运动的特征。具体而言，我们已经显示出 STC 患者整个结肠的逆行推进性压力波（PPW）幅度降低，并且中结肠的 PPW 频率降低。
提出了一种 PS 的 3D 可视化新方法，为表示大量生理数据提供了直观的方法。这些技术可用于显示频率、幅度或速度数据，并有助于向患者群体传达异常区域。
