Department of Biology, Indiana University, Bloomington, Indiana, USA.
Int Rev Cell Mol Biol. 2011;286:1-65. doi: 10.1016/B978-0-12-385859-7.00001-X.
Micro-ribonucleic acids (miRNAs) are small (21-24 nucleotide), endogenously expressed, noncoding RNAs that have emerged as important posttranscriptional regulators of gene expression. MiRNAs have been identified and cloned from diverse eukaryotic organisms where they have been shown to control important physiological and developmental processes such as apoptosis, cell division, and differentiation. A high level of conservation of some miRNAs across phyla further emphasizes their importance as posttranscriptional regulators. Research in a variety of model systems has been instrumental in dissecting the biological functions of miRNAs. In this chapter, we discuss the current literature on the role of miRNAs as developmental regulators in Drosophila.
微核糖核酸 (miRNAs) 是小型 (21-24 个核苷酸) 的内源性表达、非编码 RNA，它们已成为基因表达的重要转录后调控因子。miRNAs 已从不同的真核生物中被鉴定和克隆，它们被证明可以控制重要的生理和发育过程，如细胞凋亡、细胞分裂和分化。一些 miRNA 在门之间的高度保守性进一步强调了它们作为转录后调控因子的重要性。在各种模型系统中的研究对于解析 miRNA 的生物学功能起到了重要作用。在本章中，我们讨论了 miRNA 在果蝇中作为发育调节剂的作用的现有文献。
