长链非编码 RNA：癌症进展中的新联系。
Long intergenic noncoding RNAs: new links in cancer progression.
机构信息
Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
Cancer Res. 2011 Jan 1;71(1):3-7. doi: 10.1158/0008-5472.CAN-10-2483.
Abstract
The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.
摘要
癌症转移的过程涉及一系列连续而复杂的步骤。在这里，我们从非编码转录在癌症进展中的最新研究结果出发，重点介绍长链非编码 RNA（lincRNA）的新作用。lincRNA 靶向染色质修饰复合物或 RNA 结合蛋白，改变基因表达程序。与 miRNAs 类似，lincRNA 在原发肿瘤和转移灶中表现出不同的基因表达模式。我们讨论了 lincRNA 如何用于癌症诊断和预后，并作为潜在的治疗靶点。
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2
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