• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

(5S,6S,10R)-10-(2,4-二氯苯基)-14-[(E)-(2,4-二氯苯基)亚甲基]-3,9-二苯基-12-[(R)-1-苯乙基]-1,4,7-三氧杂-2,8,12-三氮杂-二螺[4.0.4.4]十四碳-2,8-二烯

(5S,6S,10R)-10-(2,4-Dichloro-phen-yl)-14-[(E)-(2,4-dichloro-phen-yl)methyl-idene]-3,9-diphenyl-12-[(R)-1-phenyl-ethyl]-1,4,7-trioxa-2,8,12-triaza-dispiro-[4.0.4.4]tetra-deca-2,8-diene.

作者信息

Mahalakshmi S, Kumar R Suresh, Perumal S, Sivakumar V, Suresh J

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 6;64(Pt 1):o199-200. doi: 10.1107/S1600536807063477.

DOI:10.1107/S1600536807063477
PMID:21200764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2915262/
Abstract

The asymmetric unit of the title compound, C(41)H(31)Cl(4)N(3)O(3), contains two independent mol-ecules with almost identical geometries. The piperidine ring adopts a chair conformation in both mol-ecules, and the dihydro-isoxazole rings adopt envelope conformations. The crystal structure is stabilized by C-H⋯N hydrogen bonds and C-H⋯π inter-actions.

摘要

标题化合物C(41)H(31)Cl(4)N(3)O(3)的不对称单元包含两个几何结构几乎相同的独立分子。在两个分子中，哌啶环均呈椅式构象，二氢异恶唑环呈信封式构象。晶体结构通过C-H⋯N氢键和C-H⋯π相互作用得以稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e60/2915262/105b8562882f/e-64-0o199-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e60/2915262/c3fa236aad49/e-64-0o199-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e60/2915262/105b8562882f/e-64-0o199-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e60/2915262/c3fa236aad49/e-64-0o199-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e60/2915262/105b8562882f/e-64-0o199-fig2.jpg

相似文献

1
(5S,6S,10R)-10-(2,4-Dichloro-phen-yl)-14-[(E)-(2,4-dichloro-phen-yl)methyl-idene]-3,9-diphenyl-12-[(R)-1-phenyl-ethyl]-1,4,7-trioxa-2,8,12-triaza-dispiro-[4.0.4.4]tetra-deca-2,8-diene.(5S,6S,10R)-10-(2,4-二氯苯基)-14-[(E)-(2,4-二氯苯基)亚甲基]-3,9-二苯基-12-[(R)-1-苯乙基]-1,4,7-三氧杂-2,8,12-三氮杂-二螺[4.0.4.4]十四碳-2,8-二烯
Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 6;64(Pt 1):o199-200. doi: 10.1107/S1600536807063477.
2
5''-(2,4-Dichloro-benzyl-idene)-1'-(2,4-dichloro-phen-yl)-1''-methyl-1',2',3',5',6',7',8',8a'-octa-hydro-dispiro-[acenaphthyl-ene-1,3'-indolizine-2',3''-piperidine]-2,4''(1H)-dione.5''-(2,4-二氯亚苄基)-1'-(2,4-二氯苯基)-1''-甲基-1',2',3',5',6',7',8',8a'-八氢-二螺-[苊烯-1,3'-中氮茚-2',3''-哌啶]-2,4''(1H)-二酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2906. doi: 10.1107/S1600536812037956. Epub 2012 Sep 8.
3
1'-Benzyl-4,4''-bis-(4-chloro-phen-yl)-3-(2,6-dichloro-phen-yl)-1''-methyl-4,5-dihydro-isoxazole-5-spiro-3'-piperidine-5'-spiro-3''-pyrrolidine-2''-spiro-3'''-indoline-2''',4'-dione.1'-苄基-4,4''-双-(4-氯苯基)-3-(2,6-二氯苯基)-1''-甲基-4,5-二氢异恶唑-5-螺-3'-哌啶-5'-螺-3''-吡咯烷-2''-螺-3'''-吲哚啉-2''',4'-二酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 16;66(Pt 1):o139. doi: 10.1107/S1600536809053276.
4
(5''E)-1''-Benzyl-1'-methyl-5''-[4-(methyl-sulfan-yl)benzyl-idene]-4'-[4-(methyl-sulfan-yl)phen-yl]dispiro-[indoline-3,2'-pyrrolidine-3',3''-piperidine]-2,4''-dione dichloro-methane solvate.（5''E）-1''-苄基-1'-甲基-5''-[4-（甲硫基）亚苄基]-4'-[4-（甲硫基）苯基]二螺[吲哚啉-3,2'-吡咯烷-3',3''-哌啶]-2,4''-二酮二氯甲烷溶剂合物
Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 24;66(Pt 1):o244. doi: 10.1107/S1600536809054774.
5
(3R*,4R*,5S*)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R*)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.(3R*,4R*,5S*)-4-(4-甲基-苯基)-2,3-二苯基-7-[(R*)-1-苯基-乙基]-1-氧杂-2,7-二氮杂-螺-[4.5]癸烷-10-酮肟
Acta Crystallogr Sect E Struct Rep Online. 2008 Feb 15;64(Pt 3):o590. doi: 10.1107/S1600536808004121.
6
4'-[5-(4-Fluoro-phen-yl)pyridin-3-yl]-1'-methyl-dispiro-[indan-2,2'-pyrrolidine-3',2''-indan]-1,3,1''-trione.4'-[5-(4-氟苯基)吡啶-3-基]-1'-甲基-二螺[茚满-2,2'-吡咯烷-3',2''-茚满]-1,3,1''-三酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2381-2. doi: 10.1107/S1600536811032946. Epub 2011 Aug 27.
7
Crystal structures of two 2,9-di-thia-13-aza-dispiro-[4.1.4(7).3(5)]tetra-decan-6-ones.两种2,9-二硫杂-13-氮杂-二螺-[4.1.4(7).3(5)]十四烷-6-酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Nov 21;71(Pt 12):1516-20. doi: 10.1107/S2056989015020885. eCollection 2015 Dec 1.
8
5''-(4-Meth-oxy-benzyl-idene)-7'-(4-meth-oxy-phen-yl)-1''-methyl-5',6',7',7a'-tetra-hydro-dispiro-[acenaphthene-1,5'-pyrrolo-[1,2-c][1,3]thia-zole-6',3''-piperidine]-2,4''-dione.5''-(4-甲氧基-亚苄基)-7'-(4-甲氧基-苯基)-1''-甲基-5',6',7',7a'-四氢-二螺-[苊烯-1,5'-吡咯并-[1,2-c][1,3]噻唑-6',3''-哌啶]-2,4''-二酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3210. doi: 10.1107/S1600536811045934. Epub 2011 Nov 5.
9
4-(4-Bromo-benzyl-ideneamino)-3-{1-[4-(2-methyl-prop-yl)phen-yl]eth-yl}-1-(mor-phol-ino-meth-yl)-1H-1,2,4-triazole-5(4H)-thione.4-（4-溴-亚苄基氨基）-3-{1-[4-（2-甲基丙基）苯基]乙基}-1-（吗啉代甲基）-1H-1,2,4-三唑-5（4H）-硫酮
Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 23;64(Pt 8):o1570-1. doi: 10.1107/S160053680802254X.
10
5-(4-Fluoro-benzyl-idene)-4'-(4-fluoro-phen-yl)-1,1'-dimethyl-dispiro-[piperidine-3,3'-pyrrolidine-2',3''-indoline]-4,2''-dione.5-（4-氟-亚苄基）-4'-（4-氟-苯基）-1,1'-二甲基-二螺-[哌啶-3,3'-吡咯烷-2',3''-吲哚啉]-4,2''-二酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2839-40. doi: 10.1107/S1600536812037245. Epub 2012 Sep 5.

本文引用的文献

1
Asymmetric 1,3-Dipolar Cycloaddition Reactions.不对称1,3-偶极环加成反应
Chem Rev. 1998 Apr 2;98(2):863-910. doi: 10.1021/cr970324e.
2
Marine natural products.海洋天然产物。
Nat Prod Rep. 2001 Feb;18(1):1-49. doi: 10.1039/b006897g.
3
Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety.含异恶唑部分的新型碳青霉烯类化合物的合成及抗菌活性
Bioorg Med Chem Lett. 2000 Jan 17;10(2):95-9. doi: 10.1016/s0960-894x(99)00646-0.
4
Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists.异恶唑系列糖蛋白IIb/IIIa拮抗剂的合成及抗血小板作用
Bioorg Med Chem Lett. 1998 Dec 15;8(24):3499-504. doi: 10.1016/s0960-894x(98)00637-4.
5
Isoxazoles with antipicornavirus activity.
J Med Chem. 1985 Jun;28(6):748-52. doi: 10.1021/jm00383a010.
6
A new polyhalogenated monoterpene from the red alga Plocamium cartilagineum.一种来自红藻软骨藻的新型多卤代单萜。
J Nat Prod. 1990 Nov-Dec;53(6):1615-8. doi: 10.1021/np50072a041.