Saraclar Y, McGeady S J, Mansmann H C
J Allergy Clin Immunol. 1977 Nov;60(5):301-5. doi: 10.1016/0091-6749(77)90109-9.
Recent reports note decreased T cell function in association with certain atopic conditions in man. This study was performed to determine whether numbers of circulating T cells are decreased in atopic children and adolescents in comparison with nonatopic age-matched control subjects. The subjects were not selected on the basis of a particular atopic diagnosis, but relatively more had allergic rhinitis and/or asthma (52) than had atopic eczema (7). Numbers of circulating T cells were not found to be significantly different in allergic children aged 2 to 10 yr than in control subjects. Atopic children and adolescents over age 10 yr had significantly fewer T cells in relative percentages (p less than 0.05), but when absolute numbers were considered significance was lost. Atopic children aged 2 to 10 years had significantly more B cells in both relative percentages and absolute numbers than did control subjects (p less than 0.02 and p less than 0.05, respectively). When those subjects treated with corticosteroids were separated from the total atopic group, there were no significant differences between the atopic and control subjects. The effects of corticosteroids, bronchodilators, antihistamines, and immunotherapy were considered and could be shown to produce no consistent effect on lymphocyte subpopulations.
近期报告指出，人类某些特应性疾病与T细胞功能下降有关。本研究旨在确定与年龄匹配的非特应性对照受试者相比，特应性儿童和青少年的循环T细胞数量是否减少。受试者并非基于特定的特应性诊断进行选择，但患有过敏性鼻炎和/或哮喘的人数（52人）相对多于患有特应性湿疹的人数（7人）。研究发现，2至10岁的过敏性儿童的循环T细胞数量与对照受试者相比无显著差异。10岁以上的特应性儿童和青少年的T细胞相对百分比显著减少（p<0.05），但考虑绝对数量时，差异不再显著。2至10岁的特应性儿童的B细胞相对百分比和绝对数量均显著多于对照受试者（分别为p<0.02和p<0.05）。当将接受皮质类固醇治疗的受试者从整个特应性组中分离出来时，特应性受试者与对照受试者之间无显著差异。研究考虑了皮质类固醇、支气管扩张剂、抗组胺药和免疫疗法的影响，结果表明它们对淋巴细胞亚群没有一致的影响。
