Strannegård I L, Lindholm L, Strannegård O
Int Arch Allergy Appl Immunol. 1976;50(6):684-92. doi: 10.1159/000231547.
The number of circulating T and B cells and the sensitivity of lymphocytes to stimulation with phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweek mitogen (PWM) was studied in 233 atopic children. The number of T lymphocytes was found to be decreased in cases of rhinoconjunctivitis, asthma as well as atopic eczema. Levels of B lymphocytes were normal. Sensitivity to stimulation with PHA and to a lesser degree, Con A, was significantly decreased whereas stimulation with PWM was unaffected. The severity of the atopic eczema was inversely correlated to T cell numbers. Several lines of evidence indicated that the abnormalities observed were intrinsically associated with the atopic conditions and not evoked by corticosteroid treatment. The results are compatible with the hypothesis that atopy is associated with a defect of a subpopulation of T cells. The possibility that this subpopulation has a suppressor function on reagin formation is discussed.
对233名特应性儿童的循环T细胞和B细胞数量以及淋巴细胞对植物血凝素（PHA）、刀豆蛋白A（Con A）和商陆有丝分裂原（PWM）刺激的敏感性进行了研究。发现鼻结膜炎、哮喘以及特应性皮炎患者的T淋巴细胞数量减少。B淋巴细胞水平正常。对PHA刺激的敏感性以及对Con A刺激较低程度的敏感性显著降低，而对PWM刺激则无影响。特应性皮炎的严重程度与T细胞数量呈负相关。多条证据表明，观察到的异常与特应性状况内在相关，而非由皮质类固醇治疗引起。这些结果与特应性与T细胞亚群缺陷相关的假设相符。讨论了该亚群对反应素形成具有抑制功能的可能性。
