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安他拉明

Antalarmin.

作者信息

Slauson Stephen R, Rimoldi John M, Fronczek Frank R

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 31;64(Pt 8):o1650-1. doi: 10.1107/S1600536808023775.

DOI:10.1107/S1600536808023775
PMID:21203337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2962248/
Abstract

In the mol-ecule of the title compund [systematic name: N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethyl-phen-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine], C(24)H(34)N(4), the pyrrolopy-rimidine ring system is nearly planar, its five- and six-membered rings forming a dihedral angle of 5.3 (2)°. The benzene ring is nearly orthogonal to the central ring system. The N atom carrying the ethyl and n-butyl groups is flattened pyramidal.

摘要

在标题化合物[系统名称:N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶-4-胺]的分子中,C₂₄H₃₄N₄,吡咯并嘧啶环系几乎是平面的,其五元环和六元环形成5.3 (2)°的二面角。苯环与中心环系几乎正交。携带乙基和正丁基的N原子呈扁平金字塔形。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d71/2962248/9559a9a5e156/e-64-o1650-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d71/2962248/9559a9a5e156/e-64-o1650-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d71/2962248/9559a9a5e156/e-64-o1650-fig1.jpg

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本文引用的文献

1
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Toxicology. 2008 Jun 3;248(1):8-17. doi: 10.1016/j.tox.2008.03.002. Epub 2008 Mar 13.
2
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
3
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout.
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Pharmacol Biochem Behav. 2007 Apr;86(4):813-21. doi: 10.1016/j.pbb.2007.03.009. Epub 2007 Apr 3.
4
Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists.三环促肾上腺皮质激素释放因子-1拮抗剂的设计与合成
J Med Chem. 2005 Sep 8;48(18):5780-93. doi: 10.1021/jm049085v.
5
The Cambridge Structural Database: a quarter of a million crystal structures and rising.剑桥结构数据库:拥有二十五万个晶体结构且数量不断增加。
Acta Crystallogr B. 2002 Jun;58(Pt 3 Pt 1):380-8. doi: 10.1107/s0108768102003890. Epub 2002 May 29.
6
CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.
Bioorg Med Chem. 2002 Jan;10(1):175-83. doi: 10.1016/s0968-0896(01)00261-9.
7
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Proc Natl Acad Sci U S A. 2000 May 23;97(11):6079-84. doi: 10.1073/pnas.97.11.6079.
8
Corticotropin-releasing hormone receptor subtypes and emotion.促肾上腺皮质激素释放激素受体亚型与情绪
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9
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10
Corticotropin-releasing factor receptors: an overview.
Exp Clin Endocrinol Diabetes. 1997;105(2):65-82. doi: 10.1055/s-0029-1211730.