Tanaka M, Tokunaga N, Ichikawa Y, Kaji M
First Department of Internal Medicine, Kurume University.
Kansenshogaku Zasshi. 1990 Aug;64(8):1030-6. doi: 10.11150/kansenshogakuzasshi1970.64.1030.
Since the first description of Diffuse panbronchiolitis (DPB) was published, the elevation of serum cold hemagglutinin (CHA) titer in patients with DPB has been reported, but the mechanism of its elevation is not yet clear. We investigated the relationship between the CHA titer and the indexes of inflammation (CRP, ESR, WBC, alpha 2-gl, gamma-gl), immunoglobulin, bacterial species cultured from sputum in 24 cases with DPB. They were diagnosed clinically as DPB by the criteria of the Japanese Ministry of Health and Welfare. We found no correlation between CHA titer and CRP, ESR, WBC, alpha 2-gl, gamma-gl, but there were significant correlations between the change of CHA titer and IgA, IgM. Additionally, CHA titers which were measured when Pseudomonas aeruginosa was cultured from sputum in patients with DPB were markedly high levels. These results suggest that the elevation of CHA titer does not reflect the degree of inflammations, and it occurs by immunological abnormalities.
自从弥漫性泛细支气管炎（DPB）的首次描述发表以来，已有报道称DPB患者血清冷凝集素（CHA）滴度升高，但其升高机制尚不清楚。我们调查了24例DPB患者的CHA滴度与炎症指标（CRP、ESR、WBC、α2-gl、γ-gl）、免疫球蛋白、痰液培养细菌种类之间的关系。他们根据日本厚生省的标准临床诊断为DPB。我们发现CHA滴度与CRP、ESR、WBC、α2-gl、γ-gl之间无相关性，但CHA滴度变化与IgA、IgM之间存在显著相关性。此外，DPB患者痰液培养出铜绿假单胞菌时测得的CHA滴度明显处于高水平。这些结果表明，CHA滴度升高并不反映炎症程度，而是由免疫异常引起的。
