Noda Y, Yasuoka S, Tani K, Ogura T, Ogawara M, Kitatani F
Third Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Jpn J Med. 1989 Mar-Apr;28(2):189-95. doi: 10.2169/internalmedicine1962.28.189.
The serum S-IgA levels of 33 patients with diffuse panbronchiolitis (DPB) were compared with those of 13 patients with chronic bronchitis (CB) and 24 patients with bronchiectasis (BE), to obtain information on differences in the pathologic states in DPB and other chronic bronchial diseases. The S-IgA levelw as elevated in all three bronchial diseases, being significantly higher in DPB than in CB, and intermediate in BE. Persistent bacterial infections developed in most of the patients with DPB and two-thirds of those with BE, but in few of those with CB. Serum S-IgA levels were especially high in patients expectorating Pseudomonas aeruginosa-positive sputum, who constituted two-thirds of the patients with DPB and about one-third of those with BE. The highest levels over (100 micrograms/ml) were observed in far-advanced patients with DPB who expectorated P. aeruginosa-positive sputum. The increase in the serum level of IgA was less than that of S-IgA in all three diseases. These results indicate that the marked elevation of the serum S-IgA level in patients with DPB is due to extensive, chronic infection of the airways of the lungs, especially the peripheral airways, and that serum S-IgA is a useful marker for determining the clinical stage and the pathologic state of patients with diffuse peripheral airway diseases.
将33例弥漫性泛细支气管炎（DPB）患者的血清分泌型免疫球蛋白A（S-IgA）水平与13例慢性支气管炎（CB）患者及24例支气管扩张症（BE）患者的血清S-IgA水平进行比较，以获取DPB与其他慢性支气管疾病病理状态差异的相关信息。在这三种支气管疾病中，血清S-IgA水平均升高，DPB患者的血清S-IgA水平显著高于CB患者，BE患者的血清S-IgA水平介于两者之间。大多数DPB患者和三分之二的BE患者发生了持续性细菌感染，但CB患者中很少发生。咳出铜绿假单胞菌阳性痰液的患者血清S-IgA水平尤其高，这些患者在DPB患者中占三分之二，在BE患者中约占三分之一。咳出铜绿假单胞菌阳性痰液的晚期DPB患者血清S-IgA水平最高（超过100微克/毫升）。在这三种疾病中，免疫球蛋白A（IgA）血清水平的升高均低于S-IgA血清水平的升高。这些结果表明，DPB患者血清S-IgA水平显著升高是由于肺部气道尤其是外周气道的广泛慢性感染所致，血清S-IgA是确定弥漫性外周气道疾病患者临床分期和病理状态的有用标志物。
