Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9040, USA.
Protein Cell. 2010 Apr;1(4):331-341. doi: 10.1007/s13238-010-0053-7. Epub 2010 May 8.
Circadian clocks are the internal time-keeping mechanisms for organisms to synchronize their cellular and physiological processes to the daily light/dark cycles. The molecular mechanisms underlying circadian clocks are remarkably similar in eukaryotes. Neurospora crassa, a filamentous fungus, is one of the best understood model organisms for circadian research. In recent years, accumulating data have revealed complex regulation in the Neurospora circadian clock at transcriptional, posttranscriptional, post-translational and epigenetic levels. Here we review the recent progress towards our understanding of the molecular mechanism of the Neurospora circadian oscillator. These advances have provided novel insights and furthered our understanding of the mechanism of eukaryotic circadian clocks.
生物钟是生物体将细胞和生理过程与昼夜节律同步的内部计时机制。真核生物中生物钟的分子机制非常相似。粗糙脉孢菌是一种丝状真菌，是生物钟研究中最被理解的模式生物之一。近年来，越来越多的数据揭示了Neurospora 生物钟在转录、转录后、翻译后和表观遗传水平的复杂调控。在这里，我们回顾了近年来对Neurospora 生物钟分子机制的理解进展。这些进展为我们提供了新的见解，并进一步加深了我们对真核生物钟机制的理解。
