Mathews-Roth M M, Welankiwar S, Sehgal P K, Lausen N C, Russett M, Krinsky N I
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02115.
J Nutr. 1990 Oct;120(10):1205-13. doi: 10.1093/jn/120.10.1205.
The absorption and distribution of [14C]-canthaxanthin and [14C]lycopene were studied in rats and in rhesus monkeys following the oral administration of [14C]canthaxanthin or [14C]lycopene in olive oil supplemented with 1 mg alpha-tocopherol/mL. For canthaxanthin and lycopene, peak accumulation of radioactivity in plasma occurred between 4 and 8 h in rats and between 8 and 48 h in monkeys. In rats, the liver contained the largest amount of both kinds of radioactive pigments. In monkeys, with the exception of one stomach sample, liver was also the major depot organ for both canthaxanthin and lycopene. The other organs tested accumulated various amounts of pigment. No labeled metabolic products of either canthaxanthin or lycopene were found.
在大鼠和恒河猴中，研究了在补充有1mgα-生育酚/ mL橄榄油中口服[14C]角黄素或[14C]番茄红素后，[14C]角黄素和[14C]番茄红素的吸收和分布情况。对于角黄素和番茄红素，大鼠血浆中放射性的峰值积累出现在4至8小时之间，猴子则出现在8至48小时之间。在大鼠中，肝脏含有两种放射性色素的最大量。在猴子中，除了一个胃样本外，肝脏也是角黄素和番茄红素的主要储存器官。测试的其他器官积累了不同量的色素。未发现角黄素或番茄红素的标记代谢产物。
