Rodriguez-Ortiz Carlos J., Bermúdez-Rattoni Federico
For a long time, consolidation was seen as a process achieved only on newly acquired memories aimed to store them for the long term. However, pioneer and recent studies have demonstrated that after retrieval, long-term memories may once more undergo a consolidation-like process referred to as reconsolidation. Mainly, reconsolidation is sustained by the now widely reported observation that after a memory trace is activated by means of retrieval and is susceptible to disruption by the same treatments that disrupt memory during consolidation. However, the functional purpose of this process is still a matter of debate. Recent evidence indicates that reconsolidation is indeed a process by which updated information is integrated through the synthesis of proteins to a memory trace. Hence, the so-called reconsolidation seems more like an updating consolidation intended to modify retrieved memory by a process that integrates updated experience into long-term memory. Through this process, previously consolidated memory is partially destabilized. By the infusion of disrupting agents, it appears as if the process is intended to consolidate memory again. In this chapter, we discuss this issue and propose that updating consolidation is a more descriptive term for this process.
长期以来，巩固被视为仅在新获取的记忆上实现的一个过程，旨在将它们长期存储。然而，开创性和近期的研究表明，在记忆提取后，长期记忆可能会再次经历一个类似巩固的过程，称为重新巩固。主要地，重新巩固是由现在广泛报道的观察结果所支持的，即在记忆痕迹通过提取被激活后，它容易受到在巩固过程中破坏记忆的相同处理的干扰。然而，这个过程的功能目的仍然是一个有争议的问题。最近的证据表明，重新巩固确实是一个通过蛋白质合成将更新的信息整合到记忆痕迹中的过程。因此，所谓的重新巩固似乎更像是一种更新巩固，旨在通过将更新的经验整合到长期记忆的过程来修改提取的记忆。通过这个过程，先前巩固的记忆会部分地不稳定。通过注入干扰剂，这个过程似乎是为了再次巩固记忆。在本章中，我们讨论这个问题，并提出更新巩固是这个过程更具描述性的术语。
