Pierpaoli Walter, Lesnikov Vladimir A
Interbion Foundation for Basic Biomedical Research, Gordola, Switzerland.
Curr Aging Sci. 2011 Feb;4(1):25-32. doi: 10.2174/1874609811104010025.
Adult adipose mice, high fat diet-fed (HFD) mice, anterior hypothalamus-lesioned obese mice and genetically obese mice, were injected daily with thyrotropin releasing hormone (TRH). The treatment provoked a mobilization of triglycerides in the peripheral blood, a decrease of leptin and a loss of body weight. The weight loss did not depend on TSH-mediated stimulation of thyroid hormone secretion with consequent metabolic hyperthyroidism. The levels of blood cholesterol were not affected or even suppressed. Even at a very high dosage TRH did not affect the obesity of genetically obese mice. The ubiquitous tripeptide TRH may thus constitute a key element in the hormone-controlled regulation of body weight and fat stores in the adult and aging body.
对成年肥胖小鼠、高脂饮食喂养（HFD）小鼠、下丘脑前部损伤的肥胖小鼠和遗传性肥胖小鼠，每日注射促甲状腺激素释放激素（TRH）。该治疗引发外周血中甘油三酯的动员、瘦素减少和体重减轻。体重减轻并不依赖于促甲状腺激素介导的甲状腺激素分泌刺激以及随之而来的代谢性甲状腺功能亢进。血胆固醇水平未受影响甚至降低。即使在非常高的剂量下，TRH也不会影响遗传性肥胖小鼠的肥胖状态。因此，这种普遍存在的三肽TRH可能是成年及衰老机体中激素控制体重和脂肪储存调节的关键因素。
