Department of Gastroenterology, Endocrinology and Metabolism, Philipps-University of Marburg, Germany.
Aliment Pharmacol Ther. 2011 Mar;33(5):592-600. doi: 10.1111/j.1365-2036.2010.04559.x. Epub 2011 Jan 4.
Increased prevalence of respiratory symptoms has been commonly reported in patients with gastro-oesophageal reflux disease (GERD).
To introduce a novel Lung-Sound-Monitoring device that allows simultaneous measurement of both nocturnal respiratory symptoms and episodes of acidic and biliary refluxes.
Nocturnal respiratory symptoms (coughing and wheezing) were continuously recorded in 20 healthy subjects and 30 reflux patients with respiratory symptoms in parallel to combined pH-monitoring and Bilitec measurement.
Analysis could be completed in 20 healthy subjects and in 25 patients with reflux. A clear temporal correlation to reflux phases was detected in 49% of coughing and 41% of wheezing events, respectively. Moreover, 89% of the coughing and 100% of the wheezing events succeeded reflux episodes. Finally, the technique was capable of assessing a statistically significant difference between patients and controls regarding the occurrence of these symptoms.
Our pilot study establishes the Lung-Sound-Monitoring system as a unique tool to measure objectively the temporal correlation between gastroesophageal reflux and the appearance of respiratory symptoms. It represents a useful technique to identify patients with respiratory symptoms due to reflux, and therefore allows one to determine and quantify the impact of therapeutic interventions such as antireflux therapy on respiratory symptoms.
胃食管反流病（GERD）患者常出现呼吸道症状增多的情况。
介绍一种新型的肺部声音监测设备，该设备可同时测量夜间呼吸症状以及酸反流和胆汁反流事件。
连续记录 20 名健康受试者和 30 名有呼吸道症状的反流患者的夜间呼吸症状（咳嗽和喘息），并与 pH 监测和 Bilitec 测量同时进行。
可对 20 名健康受试者和 25 名反流患者进行分析。在 49%的咳嗽事件和 41%的喘息事件中，分别检测到与反流阶段的明显时间相关性。此外，89%的咳嗽事件和 100%的喘息事件紧随反流事件发生。最后，该技术能够评估患者和对照组之间这些症状发生的统计学显著差异。
我们的初步研究确立了肺部声音监测系统作为一种独特的工具，用于客观测量胃食管反流与呼吸症状出现之间的时间相关性。它代表了一种识别因反流引起呼吸道症状的患者的有用技术，因此可以确定和量化抗反流治疗等治疗干预对呼吸症状的影响。
