Toida I, Yamamoto S
Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose.
Kekkaku. 1990 Aug;65(8):545-58.
Determination of anti-mycobacteria antibody titers by ELISA for the early diagnosis of tuberculosis was critically reviewed from methodological point of view. Especially, the method of data-handling to calculate the antibody titers from optical density values obtained by ELISA and also the method to evaluate the clinical usefulness of this test were reassessed. Determination of anti-mycobacteria antibody titer by ELISA is highly sensitive and satisfactorily specific, and far more useful than, or at least as useful as, various on-going methods for the early diagnosis of pulmonary as well as extra-pulmonary tuberculosis. This test should be included in a routine examination system for the diagnosis of tuberculosis in the clinical laboratories.
从方法论的角度对通过酶联免疫吸附测定（ELISA）检测抗分枝杆菌抗体滴度以早期诊断结核病进行了批判性综述。特别是，重新评估了从ELISA获得的光密度值计算抗体滴度的数据处理方法以及评估该检测临床实用性的方法。通过ELISA测定抗分枝杆菌抗体滴度具有高度敏感性和令人满意的特异性，并且比目前用于早期诊断肺结核和肺外结核的各种方法更有用，或者至少同样有用。该检测应纳入临床实验室结核病诊断的常规检查系统。
