The search for scrapie agent nucleic acid.
作者信息
Aiken J M, Marsh R F
机构信息
Department of Veterinary Science, University of Wisconsin-Madison 53706.
出版信息
Microbiol Rev. 1990 Sep;54(3):242-6. doi: 10.1128/mr.54.3.242-246.1990.
Abstract
Despite decades of research, the identity of the scrapie agent has remained elusive. Recent studies have discovered much about the influence of the host genome upon scrapie infection, yet relatively little is known about the causative agent itself. The predominant hypothesis in the scrapie field (the prion hypothesis) argues that the disease is the result of an infectious protein and that nucleic acid is not required for infection. Biological studies of the scrapie agent, however, suggest that a nucleic acid may be involved in the disease. Sensitive molecular biology techniques have yet to identify this putative nucleic acid.
摘要
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