2010: signaling breakthroughs of the year.

Members of the Editorial Board nominated as signaling breakthroughs insights gained from the "mega"--large-scale systems analyses--and the "micro"--protein structures--along with new findings in metabolism and genetics. In addition, research studies that may lead to new therapeutic avenues for cancer, diabetes, and Alzheimer's disease were selected as breakthroughs, along with the identification of unexpected heterogeneity of innate immune cells.