Wavre-Oberhänsli Aurélia, Nicod Laurent P
Service de pneumologie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2010 Nov 24;6(272):2240-3.
The role of Pseudomonas aeruginosa isolated in sputum cultures from adults with obstructive chronic pulmonary disease (COPD) is not well known. However, this pathogen has many factors of virulence and is responsible for several clinical manifestations in this setting. Isolation of a new strain of Pseudomonas is associated with a significant risk of exacerbation of the COPD and its prevalence depends on the severity of the COPD. The role of Pseudomonas among patients with COPD apart from exacerbations is less clear, but it could be responsible for an ignition for the airways and progression for the disease. Currently, the relevance of a prophylactic antibiotic therapy has not yet been demonstrated in COPD holders of Pseudomonas.
在患有阻塞性慢性肺病（COPD）的成年人痰液培养物中分离出的铜绿假单胞菌的作用尚不清楚。然而，这种病原体具有许多毒力因子，并在这种情况下导致多种临床表现。新的铜绿假单胞菌菌株的分离与COPD急性加重的显著风险相关，其患病率取决于COPD的严重程度。除急性加重外，铜绿假单胞菌在COPD患者中的作用尚不清楚，但它可能是气道炎症的诱因和疾病进展的原因。目前，预防性抗生素治疗在携带铜绿假单胞菌的COPD患者中的相关性尚未得到证实。
