DTU Fotonik, Technical University of Denmark, Roskilde, Denmark.
Photochem Photobiol. 2011 Mar-Apr;87(2):350-6. doi: 10.1111/j.1751-1097.2011.00887.x. Epub 2011 Jan 31.
We have demonstrated that it is possible to launch UVC LED light into bacterial contaminated polymer tubes/catheters and disinfect the intraluminal space of these tubes. This can be achieved by UVC treatment of the catheters on a regular basis. Catheters are in the distal end equipped with an exit hole for administration of drugs, bloods or nutrients into the bloodstream. Even if the UVC light is strongly attenuated during its propagation through the catheter tube a fraction of the UVC launched into the catheter will escape through the exit hole and irradiate the blood. We demonstrate by calculations that very small effective doses are exposed to the blood (ca 10(-4) J m(-2)). This dosage level is very low compared with UVC doses reported from other therapeutic applications. The very short residence time of the blood constituents in the irradiated volume in front of the exit hole is the main reason why the UVC exposure to the blood in the catheter application is so low. The very low dose received by the blood through the catheter tip indicated that possible side effects are negligible and makes the UV disinfection technique feasible in a clinical setting.
我们已经证明，将 UVC LED 光发射到受细菌污染的聚合物管/导管中，并对这些管的内腔进行消毒是可行的。这可以通过定期对导管进行 UVC 处理来实现。导管的远端配备有一个出口孔，用于将药物、血液或营养物质注入血流中。即使 UVC 光在通过导管管传播过程中被强烈衰减，仍有一部分发射到导管中的 UVC 光会从出口孔逸出并照射到血液中。我们通过计算证明，血液暴露的有效剂量非常小（约 10(-4) J m(-2))。与其他治疗应用中报告的 UVC 剂量相比，这个剂量水平非常低。在出口孔前的照射体积中，血液成分的停留时间非常短，这是导致导管应用中血液接受的 UVC 暴露如此之低的主要原因。通过导管尖端进入血液的低剂量表明，可能的副作用可以忽略不计，使得 UV 消毒技术在临床环境中可行。
