DTU Fotonik, Technical University of Denmark, Roskilde, Denmark.
J Hosp Infect. 2013 Jun;84(2):173-7. doi: 10.1016/j.jhin.2013.03.003. Epub 2013 May 10.
Disinfection of the intraluminal space of single-lumen polymer tubes can be obtained by ultraviolet C (UVC) light exposure from an external light source. In existing catheters UVC disinfection is hampered by the design of the catheter hub and tube connector.
To demonstrate that it is possible to design a single-lumen catheter with a hub, tube connector and tube parts that can be UVC-disinfected throughout its entire lumen.
Two single-lumen catheters were designed: one control and one for UVC exposure. They were contaminated with Pseudomonas aeruginosa (10(4)-10(5) cfu/mL) before UVC light exposure, sampling and plate counting.
Two minutes of UVC exposure was sufficient to obtain 4 log10 disinfection for the full-length prototype catheter. This exposure corresponds to ∼40 mJ/cm(2) at the catheter tip and indicates that even shorter exposure times can be achieved.
It is possible to design catheters that can be disinfected throughout the entire lumen. UVC light exposure could be useful as a decontamination method for catheters in clinical use.
单腔聚合物管腔内的消毒可以通过外部光源的紫外线 C（UVC）光照射来实现。在现有的导管中，UVC 消毒受到导管接头和管连接器设计的阻碍。
证明可以设计一种带有接头、管连接器和管部分的单腔导管，使其整个管腔都可以进行 UVC 消毒。
设计了两种单腔导管：一种对照导管和一种用于 UVC 暴露的导管。在进行 UVC 光暴露、采样和平板计数之前，用铜绿假单胞菌（10(4)-10(5) cfu/mL）污染这些导管。
两分钟的 UVC 暴露足以使全长原型导管获得 4 对数 10 的消毒效果。这种暴露相当于导管尖端的约 40 mJ/cm(2)，表明甚至可以实现更短的暴露时间。
可以设计出可以对整个管腔进行消毒的导管。UVC 光暴露可能是临床使用中导管消毒的一种有用方法。
