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经腋窝入路行经导管主动脉瓣植入术:主动脉瓣狭窄的血管内治疗优化。

Axillary approach for transcatheter aortic valve implantation: optimization of the endovascular treatment for the aortic valve stenosis.

机构信息

Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.

出版信息

Rev Esp Cardiol. 2011 Feb;64(2):121-6. doi: 10.1016/j.recesp.2010.08.004. Epub 2011 Jan 3.

Abstract

INTRODUCTION AND OBJECTIVES

To validate the axillary approach as a safe and efficient option for the transcatheter aortic valve implantation in patients who have contraindication for femoral approach at three Spanish hospitals.

METHODS

We included patients with severe symptomatic aortic stenosis at very high or prohibitive surgical risk, selected by a multidisciplinary team, for transcatheter aortic valve implantation, and had contraindication to the femoral approach.

RESULTS

We included 19 of 186 (10.5%) patients, who were implanted a percutaneous aortic valve, between November 2008 and March 2010. The mean age was 78.3 (standard deviation [SD]±8.65) years and 73.7% were males. The mean logistic EuroSCORE was 28.7% (SD±16.3%). The procedural success rate was 100%. After the procedure the maximum transvalve gradient decreased from 81.7 mmHg (SD±21.5) to 15.8 mmHg (SD±5.5), and no patient presented residual aortic regurgitation >2. The all-cause mortality, with a mean follow-up time of 9.2 (SD±3.2) months was 10.5%, and the in-hospital and 30-day mortality rates were 0%. The global incidence of major complications due to the procedure was 15.7%. Definitive pacemaker implantation was carried out for atrioventricular block in 8 patients (44.4%).

CONCLUSIONS

The axillary approach for transcatheter aortic valve implantation using the CoreValve(®) and contraindication to the femoral approach is safe and efficient for selected patients, with excellent results in terms of success implantation and in hospital and 30-day mortality.

摘要

介绍和目的

验证腋路入路在西班牙的 3 家医院,对因股动脉入路禁忌而不能行经导管主动脉瓣植入术的患者是一种安全有效的选择。

方法

我们纳入了经多学科团队选择的严重症状性主动脉瓣狭窄、极高或禁忌手术风险的患者,且存在股动脉入路禁忌证,进行经导管主动脉瓣植入术。

结果

2008 年 11 月至 2010 年 3 月期间,共纳入 186 例患者中的 19 例(10.5%)接受了经皮主动脉瓣植入术。患者平均年龄为 78.3 岁(标准差±8.65 岁),73.7%为男性。平均 logistic EuroSCORE 为 28.7%(标准差±16.3%)。手术成功率为 100%。手术后,跨瓣最大梯度从 81.7mmHg(标准差±21.5mmHg)降至 15.8mmHg(标准差±5.5mmHg),无患者存在残余主动脉瓣反流>2 级。平均随访时间为 9.2(标准差±3.2)个月,全因死亡率为 10.5%,院内和 30 天死亡率为 0%。因手术导致的主要并发症发生率为 15.7%。8 例(44.4%)患者因房室传导阻滞行永久性起搏器植入。

结论

腋路入路行经导管主动脉瓣植入术(使用 CoreValve(®)),对因股动脉入路禁忌而不能行经导管主动脉瓣植入术的患者是安全有效的,植入成功率高,院内和 30 天死亡率低。

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