微小RNA在癌症侵袭转移级联反应中的作用
The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade.
作者信息
Le Xiao-Feng, Merchant Omar, Bast Robert C, Calin George A
出版信息
Cancer Microenviron. 2010 Feb 23;3(1):137-47. doi: 10.1007/s12307-010-0037-4.
Abstract
Cancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in the circulation; 5) extravasation into distant organs; and 6) colonization and growth of metastatic tumors. microRNAs (miRNAs) play critical roles in this multi-step process, both promoting and suppressing metastasis. This review updates the progress made in understanding the roles of miRNAs for invasion and metastasis during cancer progression. A specific miRNA signature of cancer metastasis is also reviewed.
摘要
癌症转移是一个多步骤的级联过程，包括：1）原发性肿瘤的血管生成；2）癌细胞的脱离和侵袭；3）侵入淋巴管和血管；4）在循环系统中存活和滞留；5）外渗至远处器官；6）转移性肿瘤的定植和生长。微小RNA（miRNA）在这一多步骤过程中发挥着关键作用，既能促进也能抑制转移。本综述更新了在理解miRNA在癌症进展过程中对侵袭和转移作用方面所取得的进展。还综述了癌症转移的特定miRNA特征。
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