Centre for the Development of Best Practices in Health(CDBPH), Yaoundé Central Hospital, Avenue Henri Dunant, Messa, PO Box 87, Yaoundé, Cameroon.
Trials. 2011 Jan 7;12:5. doi: 10.1186/1745-6215-12-5.
This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic in Yaoundé, Cameroon.
This is a single-centered randomized controlled single-blinded trial. A central computer generated randomization list will be generated using random block sizes. Allocation will be determined by sequentially numbered sealed opaque envelopes. 198 participants will either receive the mobile phone text message or usual care. Our hypothesis is that weekly motivational text messages can improve adherence to Highly Active Antiretroviral Treatment and other clinical outcomes in the control group by acting as a reminder, a cue to action and opening communication channels. Data will be collected at baseline, three months and six months. A blinded program secretary will send out text messages and record delivery.Our primary outcomes are adherence measured by the visual analogue scale, self report, and pharmacy refill data. Our secondary outcomes are clinical: weight, body mass index, opportunistic infections, all cause mortality and retention; biological: Cluster Designation 4 count and viral load; and quality of life. Analysis will be by intention-to-treat. Covariates and subgroups will be taken into account.
This trial investigates the potential of SMS motivational reminders to improve adherence to Highly Active Antiretroviral Treatment in Cameroon. The intervention targets non-adherence due to forgetfulness and other forms of non-adherence.
Pan-African Clinical Trials Registry PACTR201011000261458 http://clinicaltrials.gov/NCT01247181.
本试验旨在测试每周提醒和激励性短信与常规护理相比，在提高喀麦隆雅温得诊所接受治疗的艾滋病患者对高效抗逆转录病毒治疗的依从性方面的效果。
这是一项单中心随机对照单盲试验。中央计算机将使用随机分组大小生成随机分组列表。通过编号密封的不透明信封来确定分配。将有 198 名参与者接受手机短信或常规护理。我们的假设是，每周的激励性短信可以通过提醒、行动提示和开启沟通渠道来改善对照组对高效抗逆转录病毒治疗的依从性和其他临床结果。数据将在基线、三个月和六个月时收集。一个盲法方案秘书将发送短信并记录交付情况。我们的主要结果是通过视觉模拟量表、自我报告和药物补充数据来衡量的依从性。我们的次要结果是临床结果：体重、体重指数、机会性感染、全因死亡率和保留率；生物学结果：簇设计 4 计数和病毒载量；以及生活质量。分析将采用意向治疗。将考虑协变量和亚组。
本试验研究了短信激励性提醒在改善喀麦隆艾滋病患者对高效抗逆转录病毒治疗的依从性方面的潜力。该干预措施针对的是因健忘和其他形式的不依从而导致的不依从。
泛非临床试验注册处 PACTR201011000261458 http://clinicaltrials.gov/NCT01247181。
