Cambier D, Labbé J P, Robin O
Biomedicine. 1978 May-Jun;28(3):175-80.
A hyperlipemia was obtained in rabbits injected intravenously with two carbohydrate-rich fractions isolated from crude papain dialyzate. The fractions have an approximative molecular weight of 15,000 and 5,000 daltons and contains 35% and 15% of sugars respectively. The hyperlipemia appears 20 hours after the injection and consists in a hypertriglyceridaemia as suggested by the enrichment of serum in very light lipoproteins of density about 1.006. Concomittantly a decrease of the post-heparin lipase activity (PHLA) of the plasma was observed. After a few days the hyperlipemia disappears and the PHLA returns to a normal value. It is suggested that the hypertriglyceridaemia can be due to an inhibitory effect of the injected fractions on the removal action of the lipases which are released into the blood by an heparin injection.
给兔子静脉注射从粗木瓜蛋白酶透析液中分离出的两种富含碳水化合物的组分后，兔子出现了高脂血症。这些组分的近似分子量分别为15,000和5,000道尔顿，含糖量分别为35%和15%。高脂血症在注射后20小时出现，表现为高甘油三酯血症，这可通过血清中密度约为1.006的极低密度脂蛋白的富集来表明。同时观察到血浆中肝素后脂肪酶活性（PHLA）降低。几天后，高脂血症消失，PHLA恢复到正常水平。有人提出，高甘油三酯血症可能是由于注射的组分对通过肝素注射释放到血液中的脂肪酶的清除作用具有抑制作用。
