异丙肾上腺素和去甲肾上腺素对犬五肽胃泌素刺激的胃酸分泌及黏膜血流的影响。
The effects of isoprenaline and noradrenaline on pentagastrin-stimulated gastric acid secretion and mucosal blood flow in the dog.
作者信息
Curwain B P, Holton P
出版信息
Br J Pharmacol. 1972 Oct;46(2):225-33. doi: 10.1111/j.1476-5381.1972.tb06867.x.
Abstract
- Isoprenaline (0.02 to 2.0 mug kg(-1) min(-1)) inhibited gastric secretion in response to pentagastrin in both conscious and anaesthetized dogs and in response to feeding in conscious dogs.2. The inhibition was unaffected during cardiac beta-adrenoceptor blockade by propranolol.3. The inhibition was not due to decreased mucosal blood flow.4. This effect of isoprenaline is different from its effect on histamine-induced gastric secretion.5. Noradrenaline (0.05-2.0 mug kg(-1) min(-1)) also decreased gastric secretion but it was less effective than isoprenaline.6. The mechanism of action of noradrenaline is probably a decrease in mucosal blood flow.
摘要
异丙肾上腺素（0.02至2.0微克/千克（-1）分钟（-1））可抑制清醒和麻醉犬对五肽胃泌素的胃分泌反应，以及清醒犬对进食的胃分泌反应。
在普萘洛尔对心脏β-肾上腺素能受体的阻断过程中，这种抑制作用不受影响。
这种抑制并非由于黏膜血流量减少所致。
异丙肾上腺素的这种作用与其对组胺诱导的胃分泌的作用不同。
去甲肾上腺素（0.05 - 2.0微克/千克（-1）分钟（-1））也可减少胃分泌，但效果不如异丙肾上腺素。
去甲肾上腺素的作用机制可能是黏膜血流量减少。
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Antagonism by beta-adrenoceptor blocking agents of the antianaphylactic effect of isoprenaline.β-肾上腺素能受体阻断剂对异丙肾上腺素抗过敏作用的拮抗作用。
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