异丙肾上腺素、奥西那林、沙丁胺醇和异他林对麻醉犬心血管系统作用的比较。
Comparison of the effects of isoprenaline, orciprenaline, salbutamol and isoetharine on the cardiovascular system of anaesthetized dogs.
作者信息
Ekue J M, Shanks R G, Zaidi S A
出版信息
Br J Pharmacol. 1971 Sep;43(1):23-31. doi: 10.1111/j.1476-5381.1971.tb07153.x.
Abstract
- The intravenous injection of isoprenaline, orciprenaline, salbutamol and isoetharine increased heart rate in anaesthetized dogs. Log dose-response curves obtained with a series of doses of salbutamol and isoetharine were flatter than those for isoprenaline and orciprenaline. The order of activity of the drugs in increasing heart rate was isoprenaline, orciprenaline, and salbutamol=isoetharine.2. The injection into the external iliac artery of isoprenaline, orciprenaline, salbutamol and isoetharine produced dose dependent increases in femoral blood flow. Log dose-response curves for all drugs were parallel. The order of activity of the drugs was isoprenaline, salbutamol=isoetharine and orciprenaline.3. Salbutamol and isoetharine were less active than orciprenaline in increasing heart rate but more active in increasing femoral blood flow.4. These observations indicate that salbutamol and isoetharine have a greater effect on beta(2) than on beta(1)-adrenoceptors in the cardiovascular system.
摘要
静脉注射异丙肾上腺素、奥西那林、沙丁胺醇和异他林可使麻醉犬的心率增加。用一系列剂量的沙丁胺醇和异他林得到的对数剂量-反应曲线比异丙肾上腺素和奥西那林的更平缓。药物增加心率的活性顺序为异丙肾上腺素、奥西那林、沙丁胺醇 = 异他林。
向髂外动脉注射异丙肾上腺素、奥西那林、沙丁胺醇和异他林可使股血流量产生剂量依赖性增加。所有药物的对数剂量-反应曲线平行。药物的活性顺序为异丙肾上腺素、沙丁胺醇 = 异他林、奥西那林。
沙丁胺醇和异他林在增加心率方面比奥西那林活性低，但在增加股血流量方面活性更高。
这些观察结果表明，沙丁胺醇和异他林对心血管系统中β₂肾上腺素受体的作用比对β₁肾上腺素受体的作用更大。
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