VA 高血压初级保健纵向队列：后基因组时代的电子病历。
The VA Hypertension Primary Care Longitudinal Cohort: Electronic medical records in the post-genomic era.
机构信息
University of California, San Diego, CA, USA.
出版信息
Health Informatics J. 2010 Dec;16(4):274-86. doi: 10.1177/1460458210380527.
Abstract
The Veterans Affairs Hypertension Primary Care Longitudinal Cohort (VAHC) was initiated in 2003 as a pilot study designed to link the VA electronic medical record system with individual genetic data. Between June 2003 and December 2004, 1,527 hypertensive participants were recruited. Protected health information (PHI) was extracted from the regional VA data warehouse. Differences between the clinic and mail recruits suggested that clinic recruitment resulted in an over-sampling of African Americans. A review of medical records in a random sample of study participants confirmed that the data warehouse accurately captured most selected diagnoses. Genomic DNA was acquired non-invasively from buccal cells in mouthwash; ~ 96.5 per cent of samples contained DNA suitable for genotyping, with an average DNA yield of 5.02 ± 0.12 micrograms, enough for several thousand genotypes. The coupling of detailed medical databases with genetic information has the potential to facilitate the genetic study of hypertension and other complex diseases.
摘要
退伍军人事务部高血压初级保健纵向队列（VAHC）于 2003 年启动，作为一项旨在将退伍军人事务部电子病历系统与个体基因数据联系起来的试点研究。在 2003 年 6 月至 2004 年 12 月期间，招募了 1527 名高血压参与者。保护健康信息（PHI）从区域退伍军人事务部数据仓库中提取。诊所和邮件招募之间的差异表明，诊所招募导致非裔美国人的抽样过多。对研究参与者的随机样本的医疗记录进行审查证实，数据仓库准确地捕获了大多数选定的诊断。从漱口水的口腔细胞中无创获取基因组 DNA；约 96.5%的样本含有适合基因分型的 DNA，平均 DNA 产量为 5.02±0.12 微克，足以进行数千种基因型的分析。详细的医疗数据库与遗传信息的结合有可能促进高血压和其他复杂疾病的遗传研究。
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