Department of Glaucoma, Pushpagiri Eye Institute, 241, Uma Plaza, 10-2-342, Road no 9, West Marredpally, Secunderabad-500026, Andhra Pradesh, India.
Br J Ophthalmol. 2011 May;95(5):685-8. doi: 10.1136/bjo.2010.183020. Epub 2011 Jan 8.
To determine reproducibility of peripapillary retinal nerve fibre layer thickness (RNFLT) measurements by spectral optical coherence tomography scanning laser ophthalmoscope (Spectral OCT/SLO) in normal and glaucomatous eyes.
61 normal subjects and 41 glaucoma patients underwent three RNFLT measurement by Spectral OCT/SLO in one of the eyes with a rest of 1 h between each scan. The series was repeated on three different days within 1-month period. Intrasession, intersession reproducibility of average, quadrant and clock hour RNFLT measurements were calculated for both groups. All scans were acquired by a single operator after dilation.
The intrasession intraclass coefficient correlations for mean RNFLT in normal and glaucomatous eyes were 0.994 and 0.998, respectively. The intrasession test coefficient of variation (CV) ranged from 1.2% for mean RNFLT to 5.1% for temporal clock hour in normal eyes and 1.3% for mean RNFLT to 3.6% for nasal quadrant in glaucomatous eyes. The intersession intraclass coefficient correlation for mean RNFLT in normal and glaucomatous eyes was 0.988. Intersession CV ranged from 3.96% for mean RNFLT to 9.56% for temporal clock hour in normal eyes and 3.28% for mean RNFLT to 13.39% for temporal clock hour in glaucoma patients.
The RNFLT measurement showed increased variability for narrower peripapillary areas, nasal and temporal quadrants showed higher variability than superior and inferior quadrants in normal and glaucomatous eyes. Spectral OCT/SLO demonstrated excellent intrasession and intersession reproducible measurements of peripapillary RNFLT in both groups. This finding may be useful for diagnosis and monitoring the progression of glaucoma and other optic neuropathies with spectral OCT/SLO.
通过扫频光学相干断层扫描仪（Spectral OCT/SLO）检测正常眼和青光眼患者的视盘周围视网膜神经纤维层厚度（RNFLT），评估其测量的可重复性。
61 例正常人和 41 例青光眼患者中，每只眼在 1 小时内完成 3 次 Spectral OCT/SLO 的 RNFLT 测量，每次测量之间休息 1 小时。在 1 个月内的 3 天内重复该系列。分别计算两组的平均、象限和时钟小时 RNFLT 测量的组内和组间重复性。所有扫描均由一名操作者在散瞳后进行。
正常眼和青光眼患者的平均 RNFLT 日内组内相关系数分别为 0.994 和 0.998。正常眼的平均 RNFLT 日内测试变异系数（CV）范围为 1.2%至 5.1%，而颞时钟小时的 CV 范围为 5.1%至 5.1%；青光眼患者的平均 RNFLT 日内测试 CV 范围为 1.3%至 3.6%，鼻象限的 CV 范围为 1.3%至 3.6%。正常眼和青光眼患者的平均 RNFLT 日间组内相关系数分别为 0.988。正常眼的平均 RNFLT 日间 CV 范围为 3.96%至 9.56%，颞时钟小时的 CV 范围为 9.56%至 9.56%；青光眼患者的平均 RNFLT 日间 CV 范围为 3.28%至 13.39%，颞时钟小时的 CV 范围为 3.28%至 13.39%。
视盘周围区域较窄时，RNFLT 测量的变异性增加，正常眼和青光眼患者的鼻侧和颞侧象限的变异性高于上侧和下侧象限。Spectral OCT/SLO 在两组中均显示出良好的视盘周围 RNFLT 的日内和日间可重复性测量。这一发现可能对使用 Spectral OCT/SLO 诊断和监测青光眼和其他视神经病变的进展具有重要意义。
