SERI-NTU Advanced Ocular Engineering (STANCE), Singapore.
NTU Institute of Health Technologies, Singapore.
Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):33. doi: 10.1167/iovs.61.14.33.
To evaluate the focal structure-function associations among visual field (VF) loss, optical coherence tomography angiography (OCT-A) vascular measurements, and optical coherence tomography (OCT) structural measurements in glaucoma.
In this cross-sectional study, subjects underwent standard automated perimetry, OCT-based nerve fiber thickness measurements, and OCT-A imaging. Mappings of focal VF test locations with OCT and OCT-A measurements were defined using anatomically adjusted nerve fiber trajectories and were studied using multivariate mixed-effects analysis. Segmented regression analysis was used to determine the presence of breakpoints in the structure-function associations.
The study included 119 eyes from 86 Chinese subjects with primary open-angle glaucoma (POAG). VF mean deviation was significantly associated with global capillary perfusion density (β = 0.13 ± 0.08) and global retinal nerve fiber layer thickness (β = 0.09 ± 0.02). Focal capillary density (FCD) was significantly associated with VF losses at 34 VF test locations (66.7% of 24-2 VF), with 24 of the 34 locations being within 20° of retinal eccentricity. Focal nerve layer (FNL) thickness was significantly associated with 16 VF test locations (31.4% of 24-2 VF; eight locations within 20° eccentricity). For VF test locations in the central 10° VF, VF losses below the breakpoint were significantly associated with FCD (slope, 0.89 ± 0.12, P < 0.001), but not with FNL thickness (slope, 0.57 ± 0.39, P = 0.15).
Focal capillary densities were significantly associated with a wider range of visual field losses and in a larger proportion of the visual field compared to nerve fiber thickness.
评估青光眼患者视野（VF）损失、光学相干断层扫描血管造影（OCT-A）血管测量和光学相干断层扫描（OCT）结构测量之间的局灶性结构-功能关系。
在这项横断面研究中，受试者接受了标准的自动视野检查、基于 OCT 的神经纤维厚度测量和 OCT-A 成像。使用解剖学调整后的神经纤维轨迹定义了局灶性 VF 测试位置与 OCT 和 OCT-A 测量之间的映射，并使用多变量混合效应分析进行了研究。分段回归分析用于确定结构-功能关系中是否存在断点。
该研究纳入了 86 名中国原发性开角型青光眼（POAG）患者的 119 只眼。VF 平均偏差与全视网膜毛细血管灌注密度（β=0.13±0.08）和全视网膜神经纤维层厚度（β=0.09±0.02）显著相关。局灶性毛细血管密度（FCD）与 34 个 VF 测试位置的 VF 损失显著相关（24-2 VF 的 66.7%），其中 34 个位置中有 24 个位于视网膜偏心度 20°以内。局灶性神经层（FNL）厚度与 16 个 VF 测试位置显著相关（24-2 VF 的 31.4%；8 个位置位于 20°偏心度以内）。对于中央 10°VF 中的 VF 测试位置，低于断点的 VF 损失与 FCD 显著相关（斜率为 0.89±0.12，P<0.001），但与 FNL 厚度无关（斜率为 0.57±0.39，P=0.15）。
与神经纤维厚度相比，局灶性毛细血管密度与更广泛的视野损失和更大比例的视野显著相关。
