Figliola Richard S, Giardini Alessandro, Conover Tim, Camp Tiffany A, Biglino Giovanni, Chiulli John, Hsia Tain-Yen
Departments of Mechanical Engineering and Bioengineering, Clemson University, Clemson, SC, USA.
Prog Pediatr Cardiol. 2010 Dec 1;30(1-2):71-80. doi: 10.1016/j.ppedcard.2010.09.009.
Despite the recent advances in computational modeling, experimental simulation of the circulation with congenital heart defect using mock flow circuits remains an important tool for device testing, and for detailing the probable flow consequences resulting from surgical and interventional corrections. Validated mock circuits can be applied to qualify the results from novel computational models. New mathematical tools, coupled with advanced clinical imaging methods, allow for improved assessment of experimental circuit performance relative to human function, as well as the potential for patient-specific adaptation. In this review, we address the development of three in vitro mock circuits specific for studies of congenital heart defects. Performance of an in vitro right heart circulation circuit through a series of verification and validation exercises is described, including correlations with animal studies, and quantifying the effects of circuit inertiance on test results. We present our experience in the design of mock circuits suitable for investigations of the characteristics of the Fontan circulation. We use one such mock circuit to evaluate the accuracy of Doppler predictions in the presence of aortic coarctation.
尽管最近计算建模取得了进展，但使用模拟血流回路对先天性心脏病的循环进行实验模拟仍然是设备测试以及详细了解手术和介入矫正可能产生的血流后果的重要工具。经过验证的模拟回路可用于验证新型计算模型的结果。新的数学工具与先进的临床成像方法相结合，能够更好地评估相对于人体功能的实验回路性能，以及针对特定患者进行调整的潜力。在本综述中，我们阐述了三种专门用于先天性心脏病研究的体外模拟回路的发展情况。描述了通过一系列验证和确认练习对体外右心循环回路的性能进行评估，包括与动物研究的相关性，以及量化回路惯性对测试结果的影响。我们介绍了设计适合研究Fontan循环特征的模拟回路的经验。我们使用其中一个这样的模拟回路来评估存在主动脉缩窄时多普勒预测的准确性。
