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What is a relevant statin concentration in cell experiments claiming pleiotropic effects?在声称具有多效性作用的细胞实验中，相关的他汀类药物浓度是多少？
Br J Clin Pharmacol. 2011 Jul;72(1):164-5. doi: 10.1111/j.1365-2125.2011.03907.x.
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Should we lower cholesterol as much as possible? Policy on high dose statins is startlingly absent.我们应该尽可能降低胆固醇吗？关于高剂量他汀类药物的政策竟然惊人地缺失。
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Statin therapy: not just used to lower cholesterol?他汀类药物疗法：不仅仅用于降低胆固醇？
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The role of statin therapy in preventing recurrent stroke.他汀类药物治疗在预防复发性中风中的作用。
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The Association Between Statin Drugs and Rhabdomyolysis: An Analysis of FDA Adverse Event Reporting System (FAERS) Data and Transcriptomic Profiles.他汀类药物与横纹肌溶解症之间的关联：对美国食品药品监督管理局不良事件报告系统（FAERS）数据和转录组学图谱的分析
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Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells.洛伐他汀诱导的线粒体氧化应激导致线粒体DNA释放，通过激活人结肠癌细胞中的cGAS-STING通路促进细胞凋亡。
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An In Vitro Study on the Antibacterial Activity of Statins Against the Most Common Bacterial Pathogens Causing Respiratory Tract Infections in a Tertiary Care Hospital.一项关于他汀类药物对某三级护理医院中引起呼吸道感染的最常见细菌病原体抗菌活性的体外研究。
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本文引用的文献

1
Statins enhance formation of phagocyte extracellular traps.他汀类药物增强吞噬细胞细胞外陷阱的形成。
Cell Host Microbe. 2010 Nov 18;8(5):445-54. doi: 10.1016/j.chom.2010.10.005.
2
Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation.洛伐他汀预防肝癌大鼠模型的癌变。泛醌补充的效果。
Anticancer Res. 2010 Apr;30(4):1105-12.
3
Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.他汀类药物诱导的人源和鼠源 T 细胞中 Krüppel 样因子 2 的表达可减轻炎症和致病反应。
J Clin Invest. 2010 Jun;120(6):1961-70. doi: 10.1172/JCI41384. Epub 2010 May 3.
4
Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.ABCG2 c.421C>A 单核苷酸多态性对氟伐他汀、普伐他汀和辛伐他汀药代动力学的不同影响。
Pharmacogenomics. 2009 Oct;10(10):1617-24. doi: 10.2217/pgs.09.85.
5
A simple and sensitive HPLC-UV method for quantitation of lovastatin in human plasma: application to a bioequivalence study.一种用于人血浆中洛伐他汀定量的简单灵敏的 HPLC-UV 方法：应用于生物等效性研究。
Biol Pharm Bull. 2009 Sep;32(9):1600-3. doi: 10.1248/bpb.32.1600.
6
Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy.他汀类药物诱导的大鼠肌病：全身暴露、肌肉暴露与肌病之间的关系。
Xenobiotica. 2009 Jan;39(1):90-8. doi: 10.1080/00498250802585539.
7
Anti-inflammatory effects of statins: clinical evidence and basic mechanisms.他汀类药物的抗炎作用：临床证据与基本机制
Nat Rev Drug Discov. 2005 Dec;4(12):977-87. doi: 10.1038/nrd1901.
8
Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.高剂量的辛伐他汀会影响小鼠大脑中的胆固醇合成，但普伐他汀不会。
J Pharmacol Exp Ther. 2006 Mar;316(3):1146-52. doi: 10.1124/jpet.105.094136. Epub 2005 Nov 10.
9
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.HMG-CoA还原酶抑制剂阿托伐他汀可促进Th2偏向并逆转中枢神经系统自身免疫性疾病中的麻痹状态。
Nature. 2002 Nov 7;420(6911):78-84. doi: 10.1038/nature01158.
10
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.他汀类药物通过与一个新的调节性整合素位点结合，选择性抑制白细胞功能抗原-1。
Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058.

What is a relevant statin concentration in cell experiments claiming pleiotropic effects?

作者信息

Björkhem-Bergman Linda, Lindh Jonatan D, Bergman Peter

出版信息

Br J Clin Pharmacol. 2011 Jul;72(1):164-5. doi: 10.1111/j.1365-2125.2011.03907.x.

DOI:10.1111/j.1365-2125.2011.03907.x
PMID:21223360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3141200/
Abstract
摘要