Kataria Roopam, Singhal Ajay, Prakash Sukirti, Singh Ishwar
Department of Anaesthesiology and Intensive Care, Jaipur Golden Hospital, New Delhi, India.
Indian J Anaesth. 2010 Nov;54(6):558-61. doi: 10.4103/0019-5049.72647.
Application of priming principle is well documented in relation to the use of muscle relaxants. The aim of the present study was to evaluate the efficacy of priming technique in relation to induction agents. Clinical efficacy in terms of dose reduction and alteration in peri-intubation haemodynamics was compared in propofol auto-co-induction and midazolam propofol co-induction groups along with a control group. The study was carried out in 90 patients scheduled for upper abdominal surgery, who were randomly divided into three equal groups. Group I received 0.5 mg/kg propofol IV (20% of the pre-calculated induction dose), group II received 0.05 mg/kg IV midazolam and group III received 3 ml of normal saline. This was followed by IV induction with propofol 2 minutes later in all the three groups at a predetermined rate till the bispectral index value of 45 was attained. The results showed a significant decrease in induction dose requirement in both the groups but haemodynamic stability during induction and intubation was more in propofol auto-co-induction group.
启动原则在肌肉松弛剂使用方面的应用已有充分记录。本研究的目的是评估启动技术在诱导剂方面的疗效。在丙泊酚自动协同诱导组、咪达唑仑-丙泊酚协同诱导组以及对照组中，比较了剂量减少和插管周围血流动力学改变方面的临床疗效。该研究针对90例计划进行上腹部手术的患者开展，这些患者被随机分为三个相等的组。第一组静脉注射0.5mg/kg丙泊酚（预先计算的诱导剂量的20%），第二组静脉注射0.05mg/kg咪达唑仑，第三组静脉注射3ml生理盐水。两分钟后，三组均以预定速率静脉注射丙泊酚进行诱导，直至双谱指数值达到45。结果显示，两组的诱导剂量需求均显著降低，但丙泊酚自动协同诱导组在诱导和插管期间的血流动力学稳定性更高。
