Master Program in Physical Therapy, Universidade Federal de Pernambuco, UFPE, Recife, Brazil.
Ann Biomed Eng. 2011 May;39(5):1528-34. doi: 10.1007/s10439-011-0247-z. Epub 2011 Jan 12.
The aim of this study was to quantify the effect of chemically induced diabetes mellitus (DM) on the mechanical properties of the Achilles tendon of rats and correlate it with metabolic and biomechanical findings. Adult rats were selected randomly and assigned to two groups, the diabetic group consisted of animals receiving a dose of streptozotocin to induce type I diabetes and the control group. The animals were placed in metabolic cages for analysis of metabolism. Ten weeks after diabetes induction, the Achilles tendon of both groups were collected and submitted to a traction test in a conventional testing machine. The measurements of mechanical properties indicated that the elastic modulus (MPa) was significantly higher in the control group (p < 0.01). In Maximum tension (MPa), the groups did not have differences (p > 0.01). Energy/tendon area (N mm/mm²), specific strain (%) and maximum specific strain (mm) were higher in tendon tests of the diabetic group (p < 0.01). We observed that the mechanical properties of tendons have correlations with metabolic properties of the diabetic animals. These results showed that induced DM in rats have an important negative effect on the mechanical properties of the Achilles tendon.
本研究旨在定量评估化学诱导的糖尿病（DM）对大鼠跟腱力学性能的影响，并将其与代谢和生物力学发现相关联。成年大鼠被随机选择并分为两组，糖尿病组接受链脲佐菌素（streptozotocin）剂量以诱导 1 型糖尿病，对照组则不接受任何处理。动物被放置在代谢笼中以分析代谢情况。糖尿病诱导 10 周后，收集两组大鼠的跟腱，并在常规测试机上进行牵引测试。力学性能的测量结果表明，对照组的弹性模量（MPa）显著更高（p < 0.01）。在最大张力（MPa）方面，两组之间没有差异（p > 0.01）。糖尿病组的肌腱测试中，能量/肌腱面积（N mm/mm²）、特定应变（%）和最大特定应变（mm）更高（p < 0.01）。我们观察到，肌腱的力学性能与糖尿病动物的代谢特性相关。这些结果表明，诱导的 DM 对大鼠跟腱的力学性能有重要的负面影响。
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