Huang Xinxin, Chen Xingyu, Chen Xiu, Chi Ping, Wang Pengfei, Zhan Xiaomei, Zou Chunpeng, Wang Liang, Dong Yanyan
Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 1111 Wenzhou Avenue, Longwan District, Wenzhou, 325000, China.
Diabetol Metab Syndr. 2023 Aug 21;15(1):174. doi: 10.1186/s13098-023-01148-0.
The studies of the effect of diabetes on the stiffness of Achilles tendon (AT) tissue remain inconclusive, we believe it is necessary to find a reliable method which can be used to detect the stiffness changes of the AT in the diabetic state. The objective of the present study was to investigate the effectiveness of sound touch elastography (STE) as a tool for detecting diabetic Achilles tendinopathy.
We conducted a retrospective review of 180 participants, consisting of 82 patients with type 2 diabetes mellitus (T2DM) and 98 healthy adults, who had undergone AT ultrasonography. Young 's modulus (E) values of the distal, middle, and proximal segments of bilateral ATs of all participants were measured using STE technique. The E values of each AT segment between the case and control group were compared.
The E values of the three segments of ATs in T2DM patients were lower than the healthy controls (P < 0.05). In both groups, the E values of the distal segments were lower than those of the middle segments, and the latter were lower than those of the proximal segments (P < 0.05). The E value of each segment of AT was inversely related to FPG, HbA1c, and diabetes duration (P < 0.05). The best cut-off points for the E values of the three segments of the AT for detecting diabetic tendinopathy were 347.44 kPa (AUC, 0.779), 441.57 kPa (AUC, 0.692), and 484.35 kPa (AUC, 0.676), respectively.
STE can be used as a complementary diagnostic tool for the diagnosis of diabetic Achilles tendinopathy.
糖尿病对跟腱（AT）组织硬度影响的研究尚无定论，我们认为有必要找到一种可靠的方法来检测糖尿病状态下跟腱的硬度变化。本研究的目的是探讨声触诊弹性成像（STE）作为检测糖尿病性跟腱病工具的有效性。
我们对180名参与者进行了回顾性研究，其中包括82名2型糖尿病（T2DM）患者和98名健康成年人，他们均接受了跟腱超声检查。使用STE技术测量所有参与者双侧跟腱远段、中段和近段的杨氏模量（E）值。比较病例组和对照组之间每个跟腱段的E值。
T2DM患者跟腱三段的E值均低于健康对照组（P<0.05）。在两组中，远段的E值均低于中段，中段低于近段（P<0.05）。跟腱各段的E值与空腹血糖（FPG）、糖化血红蛋白（HbA1c）和糖尿病病程呈负相关（P<0.05）。跟腱三段E值用于检测糖尿病性跟腱病的最佳截断点分别为347.44kPa（曲线下面积[AUC]，0.779）、441.57kPa（AUC，0.692）和484.35kPa（AUC，0.676）。
STE可作为诊断糖尿病性跟腱病的辅助诊断工具。
