利血平诱导的对灌注大鼠心脏中胰高血糖素的变力作用和磷酸化酶激活作用的超敏反应。
Reserpine-induced supersensitivity to the inotropic and phosphorylase activating effects of glucagon in the perfused rat heart.
作者信息
Meghji P, Tenner T E, McNeill J H
出版信息
Eur J Pharmacol. 1978 Sep 1;51(1):55-62. doi: 10.1016/0014-2999(78)90061-4.
PMID:212277
Abstract
Glucagon (0.125--2.0 microgram) produced a dose-dependent increase in cyclic AMP, % phosphorylase a and force of contraction in the isolated perfused rat heart. Pretreatment of animals with reserpine (2.5 mg/kg, 24 h) resulted in an enhancement of the inotropic and phosphorylase activating effects of glucagon but the effect on cyclic AMP was not altered. It is suggested that reserpine-induced supersensitivity in the rat heart occurs at a point beyond the cyclic AMP step.
摘要
胰高血糖素（0.125 - 2.0微克）可使离体灌注大鼠心脏中的环磷酸腺苷（cAMP）、磷酸化酶a的百分比及收缩力呈剂量依赖性增加。用利血平（2.5毫克/千克，24小时）预处理动物，可增强胰高血糖素的变力作用和磷酸化酶激活作用，但对环磷酸腺苷的作用未改变。提示利血平诱导的大鼠心脏超敏反应发生在环磷酸腺苷步骤之后的某个点。
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