Brotto Renata Squariz, Vendramini Regina Célia, Brunetti Iguatemy Lourenço, Marcantonio Rosemary Adriana Chierici, Ramos Adriana Pelegrino Pinho, Pepato Maria Teresa
Faculdade de Ciências Farmacêuticas de Araraquara - UNESP - Univ Estadual Paulista - Departamento de Análises Clínicas, SP, Brasil.
Eur J Dent. 2011 Jan;5(1):8-18.
The aim of this study was to assess a suggested association between periodontitis and renal insufficiency by assaying kidney disease markers.
VARIABLES USED TO DIAGNOSE PERIODONTITIS WERE: (i) probing pocket depth (PPD), (ii) attachment loss (AL), (iii) bleeding on probing (BOP), (iv) plaque index (PI) and (v) extent and severity index. Blood and urine were collected from 60 apparently healthy non-smokers (men and women), consisting of a test group of 30 subjects with periodontitis (age 46±6 yrs) and a control group of 30 healthy subjects (age 43±5 yrs). Kidney function markers (urea, creatinine, uric acid and albumin contents) were measured in the serum and urine. Also, the glomerular filtration rate was estimated from creatinine clearance, from the abbreviated Modification of Diet in Renal Disease formula and from the albumin : creatinine ratio in a 24-h sample of urine.
It was found that the control group had a greater mean number of teeth than the test group and that the two groups also differed in PPD, AL, BOP and PI, all these variables being higher in the test group (P=0.006). For the extent and severity index of both PPD and AL, the test group had much higher medians of both extent and severity than the control group (P=0.001). With regard to kidney function, none of the markers revealed a significant difference between the control and test groups and all measured values fell within the reference intervals.
It is proposed that severe periodontitis is not associated with any alteration in kidney function.
本研究旨在通过检测肾脏疾病标志物来评估牙周炎与肾功能不全之间的潜在关联。
用于诊断牙周炎的变量包括：（i）探诊深度（PPD），（ii）附着丧失（AL），（iii）探诊出血（BOP），（iv）菌斑指数（PI）和（v）范围及严重程度指数。从60名表面健康的非吸烟者（男性和女性）中采集血液和尿液，其中包括一个由30名牙周炎患者组成的试验组（年龄46±6岁）和一个由30名健康受试者组成的对照组（年龄43±5岁）。测量血清和尿液中的肾功能标志物（尿素、肌酐、尿酸和白蛋白含量）。此外，根据肌酐清除率、简化的肾脏疾病饮食改良公式以及24小时尿液样本中的白蛋白：肌酐比值估算肾小球滤过率。
发现对照组的平均牙齿数多于试验组，并且两组在PPD、AL、BOP和PI方面也存在差异，所有这些变量在试验组中更高（P = 0.006）。对于PPD和AL的范围及严重程度指数，试验组的范围和严重程度中位数均远高于对照组（P = 0.001）。关于肾功能，对照组和试验组之间的标志物均未显示出显著差异，所有测量值均在参考区间内。
提出重度牙周炎与肾功能的任何改变均无关联。
