Kapil Harsh, Suresh D K, Bathla Shalu Chandna, Arora Karandeep Singh
Department of Periodontology and Oral Implantology, Swami Devi Dayal Dental College and Hospital, Barwala, Panchkula, Haryana, India.
Department of Periodontology and Oral Implantology, Maharishi Markandeshwar College of Dental Sciences and Research, Mullana, Ambala, Haryana, India.
Saudi Dent J. 2018 Oct;30(4):348-354. doi: 10.1016/j.sdentj.2018.06.001. Epub 2018 Jun 11.
To evaluate the potential benefits of local application of Thymoquinone gel as an adjunctive to scaling and root planing (SRP) in subjects with chronic periodontitis.
Twenty subjects with 40 test sites were selected according to inclusion and exclusion criteria. They were further divided into 2 groups. Group I comprised of study subjects (Thymoquinone in addition to SRP) and Group II comprised of control subjects (only SRP). Clinical parameters such as Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD), Relative Attachment Level (RAL), were monitored at baseline and 6 weeks post operatively. Alkaline phosphatase (ALP) levels in gingival crevicular fluid (GCF) were evaluated at baseline and 6 weeks post operatively using microcapillaries. In addition antimicrobial efficacy of Thymoquinone was evaluated against 3 bacteria using antimicrobial strains.
Statistically highly significant reduction was observed in PI, GI and PPD, rise in RAL and GCF ALP level in both the groups at 6 weeks from baseline. On comparison between Group I and Group II, former demonstrated statistically significant reduction in PPD, GCF-ALP levels and rise in RAL but statistically no significant differences were observed in PI and GI at 6 weeks. On microbiological assessment of 0.2% Thymoquinone gel, it was observed to be sensitive against , .
Significant changes in clinical and biochemical parameters were achieved in the current study. Hence, it is concluded that intracrevicular application of 0.2% Thymoquinone gel could be a beneficial adjunct to SRP in treating chronic periodontitis.
评估在慢性牙周炎患者中，局部应用百里醌凝胶作为龈下刮治和根面平整（SRP）辅助治疗手段的潜在益处。
根据纳入和排除标准，选取20名患者共40个试验位点。这些患者被进一步分为2组。第一组为研究对象（SRP联合百里醌），第二组为对照对象（仅接受SRP）。在基线期及术后6周监测临床参数，如菌斑指数（PI）、牙龈指数（GI）、探诊深度（PPD）、相对附着水平（RAL）。使用微量毛细管在基线期及术后6周评估龈沟液（GCF）中的碱性磷酸酶（ALP）水平。此外，使用抗菌菌株评估百里醌对3种细菌的抗菌效果。
与基线相比，两组在术后6周时PI、GI和PPD均有统计学意义的显著降低，RAL和GCF中ALP水平升高。第一组和第二组比较，第一组在术后6周时PPD、GCF-ALP水平有统计学意义的显著降低，RAL升高，但PI和GI无统计学意义的差异。对0.2%百里醌凝胶进行微生物学评估，发现其对……敏感。
本研究中临床和生化参数有显著变化。因此，得出结论：在治疗慢性牙周炎时，龈沟内应用0.2%百里醌凝胶可能是SRP的有益辅助手段。
