Ness G C, Pendleton L C, Li Y C, Chiang J Y
Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612.
Biochem Biophys Res Commun. 1990 Nov 15;172(3):1150-6. doi: 10.1016/0006-291x(90)91568-d.
The effects of thyroid hormone on cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, apo A-I and farnesyl pyrophosphate synthetase hepatic mRNA levels were investigated in hypophysectomized rats. Of these mRNAs cholesterol 7 alpha hydroxylase responded the most rapidly and required the lowest dose of T3. Maximal mRNA levels were reached one hr after T3 administration and required 10 micrograms/100g of body weight. These results suggest that the hypocholesterolemic effect of thyroid hormone may be mediated by a primary effect on cholesterol 7 alpha hydroxylase gene expression.
