缺失环节：细胞色素 P450 花生四烯酸产物一类新型的脂质介质。

Missing links: Cytochrome P450 arachidonate products A new class of lipid mediators.

机构信息

John C. McGiff, Melody Steinberg, and John Quilley are at the Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA.

出版信息

Trends Cardiovasc Med. 1996 Jan;6(1):4-10. doi: 10.1016/1050-1738(95)00106-9.

DOI:10.1016/1050-1738(95)00106-9

PMID:21232268

Abstract

Three major enzyme systems-cyclooxygenases, lipoxygenases, and cytochrome P450 monooxygenases (CYP)-generate biological mediators from arachidonic acid (AA). A distinct profile of arachidonate products characterizes each renal tubular segment and each section of the renal vascular tree from arteries to microvessels to veins. The most recent discoveries on renal mechanisms subserved by arachidonate metabolites relate to CYP pathways of AA metabolism. These arachidonate products have prominent effects on blood vessels and ion transport, including modulation and mediation of the actions of vasoactive hormones. The diverse properties of these AA metabolites and the wide distribution of the CYP system make them prime candidates for participation in regulatory mechanisms that affect the circulation and transporting epithelia. CYP-AA products are as important to renal and circulatory control as are nitric oxide and prostaglandins.

摘要

三种主要的酶系统——环氧化酶、脂氧合酶和细胞色素 P450 单加氧酶（CYP）——从花生四烯酸（AA）生成生物介质。每个肾单位和肾血管树的每一段（从动脉到微血管再到静脉）都有独特的花生四烯酸产物特征。最近关于花生四烯酸代谢物所发挥的肾机制的发现与 CYP 途径有关。这些花生四烯酸产物对血管和离子转运有显著影响，包括调节和介导血管活性激素的作用。这些 AA 代谢产物的多样性和 CYP 系统的广泛分布使它们成为参与影响循环和转运上皮的调节机制的主要候选物。CYP-AA 产物对肾脏和循环的控制与一氧化氮和前列腺素一样重要。