Department of Diagnostic Radiology, University of Giessen, Germany.
Acad Radiol. 2011 Feb;18(2):230-4. doi: 10.1016/j.acra.2010.10.006.
To evaluate the feasibility of micro computed tomography (CT) to assess the fine structure of breast tissue.
Breast core needle biopsy specimens (0.8 to 1.2 mm diameter) from fifteen women with clustered microcalcifications were examined using micro CT with isotropic voxels of 8.4 μm. Reconstructed two- and three-dimensional images were compared with the corresponding histological slices. Gray-scale measurements were performed in adipose tissue, fibroglandular tissue, fibrous tissue, microcalcifications, and tumor. The Tukey-Kramer method was applied to test the statistically significant differences between gray-scale attenuation values of breast tissue components.
Soft-tissue architecture appearance at micro CT closely approximated that obtained by light microscopy at low power field. The Tukey-Kramer method revealed statistically significant differences for attenuation values for all combinations of breast tissue components with the exception of fibroglandular tissue versus fibrous tissue.
Micro CT is feasible for the differentiation of breast tissue components from core needle specimens.
评估微计算机断层扫描（CT）评估乳腺组织精细结构的可行性。
对 15 名簇状微钙化妇女的乳腺芯针活检标本（直径 0.8 至 1.2 毫米）进行微 CT 检查，体素分辨率为 8.4 μm。重建的二维和三维图像与相应的组织切片进行比较。对脂肪组织、纤维腺体组织、纤维组织、微钙化和肿瘤进行灰度测量。采用 Tukey-Kramer 法检验乳腺组织成分灰度衰减值之间的统计学显著差异。
微 CT 软组织结构外观与低倍光镜下的观察结果非常相似。Tukey-Kramer 法显示除纤维腺体组织与纤维组织外，所有乳腺组织成分的衰减值组合均存在统计学显著差异。
微 CT 可用于从芯针标本中区分乳腺组织成分。
