Lev-Toaff A S, Feig S A, Saitas V L, Finkel G C, Schwartz G F
Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
Radiology. 1994 Jul;192(1):153-6. doi: 10.1148/radiology.192.1.8208928.
To determine the frequency of stability in malignant microcalcifications and its relationship to specific histologic diagnoses.
During a 34-month period, microcalcifications were proved malignant in 182 patients referred for needle-guided biopsy. In 105 patients, the mammograms were compared with one or more than one previous mammogram. These patients were classified on the basis of interval change in two groups: those with stable and those with increasing or new microcalcifications. The histologic diagnoses were reviewed.
Microcalcifications were stable for 8-63 months (mean, 25.4 months) in 26 patients (24.8%), only three (12%) of whom had invasive ductal carcinoma, which was found in 29 (37%) of the 79 patients with increasing or new microcalcifications.
The odds for presence of invasive ductal carcinoma are statistically significantly lower (P < .025) among patients with stable microcalcifications than among those with increasing or new microcalcifications. Stability of indeterminate or suspicious microcalcifications is unreliable for exclusion of a diagnosis of malignancy.
确定恶性微钙化的稳定性频率及其与特定组织学诊断的关系。
在34个月的时间里，182例接受针引导活检的患者被证实存在恶性微钙化。在105例患者中，将乳腺X线照片与一张或多张先前的乳腺X线照片进行比较。根据间隔变化将这些患者分为两组：微钙化稳定的患者和微钙化增多或出现新微钙化的患者。对组织学诊断进行回顾。
26例患者（24.8%）的微钙化稳定8至63个月（平均25.4个月），其中只有3例（12%）患有浸润性导管癌，而在79例微钙化增多或出现新微钙化的患者中，有29例（37%）患有浸润性导管癌。
微钙化稳定的患者中存在浸润性导管癌的几率在统计学上显著低于微钙化增多或出现新微钙化的患者（P <.025）。不确定或可疑微钙化的稳定性对于排除恶性肿瘤诊断并不可靠。
