School of Biological Sciences, The Queen's University of Belfast, 97 Lisburn Road, Belfast, Ireland.
Vet Parasitol. 2011 Apr 19;177(1-2):179-81. doi: 10.1016/j.vetpar.2010.11.043. Epub 2010 Dec 3.
Hares (Lepus europeanus) sharing pasture with cattle from six locations in the Netherlands were examined for the presence of liver fluke (Fasciola hepatica) and shown to have prevalences of infection ranging from 0 to 41%. The mitochondrial haplotypes of liver flukes present in the hare populations were determined and compared with those found in cattle from a farm where triclabendazole resistance has been reported. Phylogenetic analysis indicated that the flukes present in the hares belonged to the same clades as those present in the cattle. A consideration of the life cycle of the liver fluke and the seasonal breeding pattern and ecology of hares supports the suggestion that hares may act as a refugia for liver fluke and as a vector for the spread of drug-resistant genotypes.
从荷兰的六个地点与牛共享牧场的野兔（欧洲兔），检查是否存在肝片吸虫（Fasciola hepatica），结果显示感染率从 0 到 41%不等。确定了存在于野兔种群中的肝吸虫的线粒体单倍型，并与来自一个已报告三氯苯达唑耐药性的农场的牛进行了比较。系统发育分析表明，存在于野兔中的吸虫与存在于牛中的吸虫属于同一进化枝。考虑到肝吸虫的生命周期以及野兔的季节性繁殖模式和生态学，这表明野兔可能是肝吸虫的避难所，并可能成为耐药基因型传播的媒介。
