Biomedical Research Centre, University of Oxford, UK.
AJNR Am J Neuroradiol. 2011 Feb;32(2):238-43. doi: 10.3174/ajnr.A2346. Epub 2011 Jan 13.
The purpose of this study was to review current treatment options in acute ischemic stroke, focusing on the latest advances in the field of mechanical recanalization. These devices recently made available for endovascular intracranial thrombectomy show great potential in acute stroke treatments. Compelling evidence of their recanalization efficacy comes from current mechanical embolectomy trials. In addition to allowing an extension of the therapeutic time window, mechanical recanalization devices can be used without adjuvant thrombolytic therapy, thus diminishing the intracranial bleeding risk. Therefore, these devices are particularly suitable in patients in whom thrombolytic therapy is contraindicated. IV and IA thrombolysis and bridging therapy are viable options in acute stroke treatment. Mechanical recanalization devices can potentially have a clinically relevant impact in the interventional treatment of stroke, but at the present time, a randomized study would be beneficial.
本研究旨在回顾急性缺血性脑卒中的当前治疗选择，重点关注机械再通领域的最新进展。这些最近可用于血管内颅内血栓切除术的设备在急性脑卒中治疗中显示出巨大的潜力。目前机械取栓试验提供了令人信服的再通疗效证据。除了能够延长治疗时间窗外，机械再通设备可以在不辅助溶栓治疗的情况下使用，从而降低颅内出血风险。因此，这些设备特别适用于溶栓治疗禁忌的患者。静脉内和动脉内溶栓及桥接治疗是急性脑卒中治疗的可行选择。机械再通设备在脑卒中的介入治疗中可能具有重要的临床意义，但目前进行随机研究将是有益的。
