Squitti Rosanna, Salustri Carlo, Siotto Mariacristina, Ventriglia Mariacarla, Vernieri Fabrizio, Lupoi Domenico, Cassetta Emanuele, Rossini Paolo M
Department of Neuroscience, AFaR-Fatebenefratelli Hospital, 00186 Rome, Italy.
Int J Alzheimers Dis. 2010 Dec 27;2011:231595. doi: 10.4061/2011/231595.
The link between iron and Alzheimer's disease (AD) has been mainly investigated with a focus on the local accumulation of this metal in specific areas of the brain that are critical for AD. In the present study, we have instead looked at systemic variations of markers of iron metabolism. We measured serum levels of iron, ceruloplasmin, and transferrin and calculated the transferrin saturation and the ceruloplasmin to transferrin ratio (Cp/Tf). Cp/Tf and transferrin saturation increased in AD patients. Cp/Tf ratios also correlated positively with peroxide levels and negatively with serum iron concentrations. Elevated values of ceruloplasmin, peroxides, and Cp/Tf inversely correlated with MMSE scores. Isolated medial temporal lobe atrophy positively correlated with Cp/Tf and negatively with serum iron. All these findings indicate that the local iron accumulation found in brain areas critical for AD should be viewed in the frame of iron systemic alterations.
铁与阿尔茨海默病（AD）之间的联系主要围绕这种金属在大脑中对AD至关重要的特定区域的局部积累展开研究。在本研究中，我们转而关注铁代谢标志物的全身变化。我们测量了血清中铁、铜蓝蛋白和转铁蛋白的水平，并计算了转铁蛋白饱和度以及铜蓝蛋白与转铁蛋白的比率（Cp/Tf）。AD患者的Cp/Tf和转铁蛋白饱和度升高。Cp/Tf比率还与过氧化物水平呈正相关，与血清铁浓度呈负相关。铜蓝蛋白、过氧化物和Cp/Tf的升高值与简易精神状态检查表（MMSE）评分呈负相关。孤立的内侧颞叶萎缩与Cp/Tf呈正相关，与血清铁呈负相关。所有这些发现表明，在对AD至关重要的脑区中发现的局部铁积累应在铁全身改变的框架内看待。
