Ding Bei, Chen Ke-Min, Ling Hua-Wei, Sun Fei, Li Xia, Wan Tao, Chai Wei-Min, Zhang Huan, Zhan Ying, Guan Yong-Jing
Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
J Magn Reson Imaging. 2009 Apr;29(4):793-8. doi: 10.1002/jmri.21730.
To investigate the brain iron deposits in patients with Alzheimer's disease (AD) and healthy age-matched controls using phase imaging.
Twenty-six AD patients and 24 healthy controls were recruited. A three-dimensional high-resolution, gradient-echo sequence was used to acquire phase data in the coronal plane. A high-pass filter was used to remove the phase variation caused by field inhomogeneity. The regions evaluated included the bilateral putamen, globus pallidus, and the head and body of the hippocampus.
Significantly lower phase values in both the basal ganglion and hippocampus were revealed in the AD group compared to the normal controls (P < 0.05). The phase value in the right side of the head of the hippocampus had a moderate positive correlation with the MMSE score (r= 0.603, P = 0.000) and a negative correlation with the duration of the disease (r = -0.677, P = 0.013). Using -0.0972 radians as an optimal cutoff value, the sensitivity and specificity for differentiation between AD and normal controls reached 95.8 and 80.8%, respectively.
Phase imaging proved to be a useful method for the differentiation between normal controls and AD patients. An investigation of the excessive accumulation of iron in the hippocampus may help us better understand the pathologic process and neuropsychological dysfunction of AD disease.
使用相位成像技术研究阿尔茨海默病（AD）患者和年龄匹配的健康对照者的脑铁沉积情况。
招募了26例AD患者和24例健康对照者。使用三维高分辨率梯度回波序列在冠状面采集相位数据。使用高通滤波器去除由场不均匀性引起的相位变化。评估的区域包括双侧壳核、苍白球以及海马头部和体部。
与正常对照组相比，AD组基底节和海马的相位值显著降低（P < 0. – 05）。海马头部右侧的相位值与简易精神状态检查表（MMSE）评分呈中度正相关（r = 0.603，P = 0.000），与病程呈负相关（r = -0.677，P = 0.013）。以-0.0972弧度作为最佳截断值，AD与正常对照者鉴别的敏感性和特异性分别达到95.8%和80.8%。
相位成像被证明是区分正常对照者和AD患者的一种有用方法。对海马中铁过度积累的研究可能有助于我们更好地理解AD疾病的病理过程和神经心理功能障碍。
