5-羟色胺转运体（5-HTT）、5-羟色胺受体2A（5-HTR2A）和γ-氨基丁酸A型受体α6亚基（GABRA6）基因多态性与健康相关人格特质之间的关联分析。

Analysis of associations between 5-HTT, 5-HTR2A, and GABRA6 gene polymorphisms and health-associated personality traits.

作者信息

Alfimova M V, Monakhov M V, Golimbet V E, Korovaitseva G I, Lyashenko G L

机构信息

Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2010 Oct;149(4):434-6. doi: 10.1007/s10517-010-0964-6.

DOI:10.1007/s10517-010-0964-6

PMID:21234437

Abstract

The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neuroticism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.

摘要

由尽责性概念统一起来的人格特质的发展，应该在减轻焦虑的同时促进身心健康。为了探究尽责性和神经质形成的根源，我们评估了一组369名志愿者中5-HTT、5-HTR2A和GABRA6基因的多态性标记与TCI问卷相关分数之间的关联。检测到5-HTT基因的VNTR和LPR标记以及GABRA6基因的T1521C标记与“自我导向性”的关联，以及5-HTR2A基因标记T102C及其与GABRA6基因的相互作用对“回避伤害”的影响。